MyBiosource
MBS488361 | Anti-Fas [R-125224]
- SKU:
- MBS488361
- Availability:
- Usually Shipped in 5 Working Days
Description
Anti-Fas [R-125224] | MBS488361 | Mybiosource
Product Short Name: [Fas]
Product Name Synonyme: [h-HFE7A; Tumor necrosis factor receptor superfamily member 6; CD95; CD-95; Apo-1; Apo 1; Apo-1 antigen; Apoptosis-mediating surface antigen FAS; FASLG receptor]
Other Names: [tumor necrosis factor receptor superfamily member 6 isoform 1; Tumor necrosis factor receptor superfamily member 6; tumor necrosis factor receptor superfamily member 6; Fas cell surface death receptor; Apo-1 antigen; Apoptosis-mediating surface antigen FAS; FASLG receptor; CD_antigen: CD95]
Product Gene Name: [Fas]
Product Gene Name Synonyme: N/A
Other Gene Names: [FAS; FAS; APT1; CD95; FAS1; APO-1; FASTM; ALPS1A; TNFRSF6; APT1; FAS1; TNFRSF6]
Clonality: Monoclonal
Isotype: Human IgG1, Kappa
Clone: [R-125224]
Host: N/A
Reactivity: Human
Specificity: R-125224 binds to the extracellular portion of human Fas at an eptiope consisting of the sequence RTQNTKCRCK (aa 105-114) (pmid: 11754745). Fas is a type I membrane protein which belongs to the tumor necrosis factor (TNF) receptor/nerve growth factor (NGF) receptor superfamily. It is able to transduce apoptotic signals into the cell when bound by its ligand FasL (Fas ligand), which is primarily expressed in activated T lymphoid-myeloid lineage cells, in the eye, in reproductive organs and in some tumors. The Fas-FasL system is known to play an important role in maintaining the immune system as mice with Fas-defective lymphoproliferation (lpr) and FasL-defective generalized lymphoproliferative disease (gld) mutations develop massive lymphadenopathy and autoimmune diseases.
Purity: Protein A Affinity Purified
Form: N/A
Concentration: 1 mg/ml
Storage Stability: Store at 4 degree C for up to 3 months. For longer storage, aliquot and store at -20 degree C.
Tested Application: Activate, Imaging, ELISA (EIA), Flow Cytometry (FC/FACS)