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Doug Markham has contributed a molecular mechanics computation of the structure! See below for the details.
Config Rule :
Smiles String :
Fischer Diagram :
The Terminals for all the Config Rules are in Prolog Definite Clause Grammar (DCG) form.They can be checked in the Manual here.
The compound's PDB file can be seen here.
Doug Markham of the Institute for Cancer Research, Fox Chase Cancer Center,Philadelphia, PA, has contributed the following structure for Pi. He computed this structure in sdf format using MacroModel, a molecular mechanics program. We have used Babel to convert the .sdf format to PDB format. You'll find it interesting to compare these structures to those computed using CONCORD.
Many thanks Doug!
Pi, or inorganic phosphate, is an essential nutrient for all living organisms. It is a component of DNA, RNA, and ATP, the energy currency of cells. Pi is also involved in a variety of other biological processes, such as cell signaling, metabolism, and bone health.
Here are some specific examples of the role of Pi in biology:
- DNA and RNA synthesis: Pi is a component of the nucleotides that make up DNA and RNA. Nucleotides are the building blocks of genetic material, and Pi is essential for their synthesis.
- ATP production: ATP is the energy currency of cells. It is used to power all cellular processes. Pi is released during the breakdown of ATP, and it is also required for the synthesis of new ATP.
- Cell signaling: Pi is involved in a variety of cell signaling pathways. For example, Pi can bind to proteins and activate them, which can lead to changes in gene expression or cell behavior.
- Metabolism: Pi is involved in a variety of metabolic pathways, including glycolysis, the Krebs cycle, and the electron transport chain. These pathways are responsible for breaking down food molecules and producing energy for cells.
- Bone health: Pi is a component of hydroxyapatite, the mineral that gives bones their strength. Pi is also involved in the regulation of bone metabolism.
A deficiency in Pi can lead to a number of health problems, including anemia, muscle weakness, and bone problems. Conversely, too much Pi can also be harmful, and it can lead to conditions such as hyperphosphatemia and kidney stones.
Overall, Pi is an essential nutrient for all living organisms. It plays a vital role in a variety of biological processes, including DNA and RNA synthesis, ATP production, cell signaling, metabolism, and bone health.
Inorganic phosphate (Pi) is an essential nutrient that plays a crucial role in many biological processes, including bone development and mineralization. Pi homeostasis is tightly regulated, and any deviation from normal levels can lead to a variety of acute and chronic diseases, including aging and shortened lifespan.
Pi is abundant in the diet and is efficiently absorbed by the intestines. The kidneys are the primary regulators of Pi homeostasis, and can increase or decrease Pi reabsorption depending on the body's needs.
In recent years, Pi has emerged as an important signaling molecule that can modulate multiple cellular functions by altering signal transduction pathways, gene expression, and protein abundance. However, the exact mechanisms by which Pi is sensed and how it signals to downstream targets are not fully understood.
Researchers have shown that Pi can inhibit the proliferation and aggressiveness of human osteosarcoma cells by affecting the expression and function of key proteins, such as adenylate cyclase, beta3 integrin, Rap1, and ERK1/2.
More recently, it has been shown that Pi can also sensitize osteosarcoma cells to the chemotherapy drug doxorubicin in a p53-dependent manner, involving the downregulation of ERK1/2.
These findings suggest that targeting Pi levels at local sites could be a promising new strategy for improving osteosarcoma therapy.
Overall, Pi is a versatile and important molecule with a wide range of biological functions. More research is needed to fully understand the role of Pi signaling in health and disease.