MBS3001774 | Thrombin R (G17) Polyclonal Antibody
- Usually Shipped in 5 Working Days
Thrombin R (G17) Polyclonal Antibody | MBS3001774 | Mybiosource
Product Short Name: [Thrombin R]
Product Name Synonyme: [Proteinase-activated receptor 1; PAR-1; Coagulation factor II receptor; Thrombin receptor; F2R; CF2R; PAR1; TR]
Other Names: [proteinase-activated receptor 1 isoform 1; Proteinase-activated receptor 1; proteinase-activated receptor 1; coagulation factor II thrombin receptor; Coagulation factor II receptor; Thrombin receptor]
Product Gene Name: [G17]
Product Gene Name Synonyme: N/A
Other Gene Names: [F2R; F2R; TR; HTR; CF2R; PAR1; PAR-1; CF2R; PAR1; TR; PAR-1]
Reactivity: Human, Mouse, Rat
Specificity: Thrombin R (G17) polyclonal antibody detects endogenous levels of Thrombin R protein
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
Form: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Storage Stability: Store at 4 degree C short term.
Aliquot and store at -20 degree C long term.
Avoid freeze-thaw cycles.
Tested Application: Western Blot (WB)
Related Product Information:
Thrombin receptor (also designated protease-activated receptor-1 or PAR-1), PAR-2 and PAR-3 compose a distinct class of G protein-coupled receptors activated by proteolysis. Cleavage of these receptors by proteases occurs within the amino-terminal extracellular domain. Thrombin, a serine protease involved in platelet aggregation and blood coagulation, activates the thrombin receptor, resulting in elevated intracellular calcium levels in platelets. Thrombin also cleaves PAR-3 in vitro, suggesting that PAR-3 may be involved in thrombosis or mitogenesis. Thrombin receptor and PAR-4 appear to account for most thrombin signaling in platelets. Activation of PAR-2 in vitro is induced by trypsin, suggesting that PAR-2 is not an alternative thrombin receptor. Cytokines including TNF-alpha and IL-1beta increase PAR-2 expression, indicating PAR-2 involvement in the acute inflammatory response.