L-methionine

Methionine (IUPAC-IUBMB abbreviations: Met and M) is an α-amino acid, with its L enantiomer being one of the 22 proteinogenic amino acids, and one of the 9 essential amino acids for humans. It is encoded in messenger RNA by the AUG codon. It is characterized by the presence of a sulfur atom engaged in a thioether function. Its methyl group –CH3 is involved in numerous methylation reactions within the metabolism.

Methionine plays a critical role in reproduction, cell development, and DNA and protein methylation.

MBS405359 | L-Methionine
MBS545035 | S-Adenosyl-L-methionine
MBS545911 | L-METHIONINE
MBS645382 | Nitroso-L-Methionine (NO-L-Methionine), Conjugated
MBS647166 | L-Methionine, Conjugated
MBS842054 | S-Adenosyl-L-methionine disulfate tosylate
MBS845893 | L-Methionine y-Lase Polyclonal Antibody
MBS6014802 | L-Methionine-S-methyl Sulfonium Chloride-d6
MBS6063486 | S-(5'-Adenosyl)-L-methionine
MBS6065043 | S-(5'-Adenosyl)-L-methionine-d3
MBS6086356 | L-Methionine [R]-Sulfoximine
MBS6102151 | L-Methionine-d3
MBS6102179 | L-Methionine
MBS6113736 | L-Methionine [S]-Sulfoximine
MBS3608711 | S-(5'-Adenosyl)-L-methionine tosylate
MBS3609591 | N-Formyl-L-methionine
MBS3609639 | L-Methionine
MBS3611365 | N-Acetyl-L-methionine
MBS4158205 | Anti-Conjugated NO-L-Methionine Antibody
MBS5750561 | S-(5'-Adenosyl)-L-methionine tosylate

 

Methionine is a crucial amino acid for protein synthesis and cellular growth. As a precursor to S-adenosylmethionine, an important methyl group donor in methylation reactions, it is essential for numerous key metabolic pathways. Additionally, methionine is involved in the formation of carnitine, a compound vital for the transport of fatty acids into mitochondria, where they are used as an energy source.

Moreover, methionine is often used as a dietary supplement for its potential health benefits. In addition to promoting growth and development, it can contribute to the health of hair, skin, and nails. Methionine also plays a critical role in detoxification by helping to eliminate heavy metals and other toxins from the body.


Accession Number : KLM0000272 This work is released into the public domain; please see our release statement.

l-methionine-3d.gif

Synonyms :

 

  • L-METHIONINE
  • Met
  • M

 

Config Rule :

 

config('L-methionine',[
        substituent(aminoacid_L_backbone),
        substituent(methandiylthiomethyl),
        linkage(from(aminoacid_L_backbone,car(1)),
                to(methandiylthiomethyl,car(1)),
                down,single)]).

%%%% Substituent Config Rules for compound 'L-methionine' %%%%

config(aminoacid_L_backbone,[
        left(amino),
        right(hyd),
        top(carboxyl),
        center(car(1))]).

config(methandiylthiomethyl,[
        top(methandiyl(1,empty)),
        center(methandiyl),
        bottom(sul(1,methyl))]).

Smiles String :

 

[C@2H]([NH3+])([C](=[O])[O-])[C@2H2][C@2H2][S][CH3]

'L-methionine'

Fischer Diagram :

 

Terminal :

% 'L-methionine'

c(1,12,(0,chiral))-[n(1,left)~,h(1,right)~,c(2,up)~,c(3,down)~],
c(2,12,(0,nonchiral))-[o(1,nil)?,o(2,nil)?,c(1,down)~],
c(3,12,(0,nonchiral))-[c(4,left)~,h(7,right)~,c(1,up)~,h(8,down)~],
c(4,12,(0,nonchiral))-[h(5,left)~,c(3,right)~,h(6,up)~,s(1,down)~],
c(5,12,(0,nonchiral))-[h(9,left)~,h(11,right)~,s(1,up)~,h(10,down)~],
h(1,1,(0,nonchiral))-[c(1,left)~],
h(2,1,(0,nonchiral))-[n(1,right)~],
h(3,1,(0,nonchiral))-[n(1,down)~],
h(4,1,(0,nonchiral))-[n(1,up)~],
h(5,1,(0,nonchiral))-[c(4,right)~],
h(6,1,(0,nonchiral))-[c(4,down)~],
h(7,1,(0,nonchiral))-[c(3,left)~],
h(8,1,(0,nonchiral))-[c(3,up)~],
h(9,1,(0,nonchiral))-[c(5,right)~],
h(10,1,(0,nonchiral))-[c(5,up)~],
h(11,1,(0,nonchiral))-[c(5,left)~],
n(1,14,(1,nonchiral))-[h(2,left)~,c(1,right)~,h(3,up)~,h(4,down)~],
o(1,16,(-5.0E-01,nonchiral))-[c(2,nil)?],
o(2,16,(-5.0E-01,nonchiral))-[c(2,nil)?],
s(1,32,(0,nonchiral))-[c(5,down)~,c(4,up)~]

The Terminals for all the Config Rules are in Prolog Definite Clause Grammar (DCG) form.They can be checked in the Manual here.

The compound's PDB file can be seen here.