MBS4380465 | MTAP (Tumor Suppressor Marker)

MTAP (Tumor Suppressor Marker) | MBS4380465 | Mybiosource

Product Short Name: [MTAP]

Product Name Synonyme: [BDMF; DMSFH; DMSMFH; Epididymis luminal protein 249; HEL249; LGMBF; MeSAdo phosphorylase; Methylthioadenosine phosphorylase; MSAP; MTA phosphorylase; MTAP; MTAPase; S-methyl-5''-thioadenosine phosphorylase]

Other Names: [S-methyl-5'-thioadenosine phosphorylase; S-methyl-5'-thioadenosine phosphorylase; S-methyl-5'-thioadenosine phosphorylase; methylthioadenosine phosphorylase; 5'-methylthioadenosine phosphorylase]

Product Gene Name: [MTAP]

Product Gene Name Synonyme: N/A

Other Gene Names: [MTAP; MTAP; BDMF; MSAP; DMSFH; LGMBF; DMSMFH; c86fus; HEL-249; MTA phosphorylase; MTAP; MTAPase]

Clonality: Monoclonal

Isotype: IgG2b, kappa

Clone: [MTAP/1813]

Host: Mouse

Reactivity: Human. Others not known.

Specificity: Recognizes a protein of 31kDa, which is identified as MTAP (5'-deoxy-5'-methylthioadenosine phosphorylase). It catalyzes the reversible phosphorolysis of methylthioadenosine, which is important in polyamine metabolism and for the salvage of adenine and methionine. The gene encoding MTAP is linked to the tumor suppressor gene, p16INK4A. Deficient levels of MTAP can occur in cancers primarily through co-deletion of the MTAP gene and the p16INK4A gene. Cells expressing MTAP and possessing adenine salvage pathway activity may be less susceptible to malignancy due to growth-inhibitory actions of agents (e.g. antifolates), whose mechanism of action, in part, involves this de novo purine pathway.

Purity: N/A

Form: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Concentration: N/A

Storage Stability: N/A

Tested Application: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC) Formalin