MBS4380201 | Rb1 (Tumor Suppressor Protein)

Rb1 (Tumor Suppressor Protein) | MBS4380201 | Mybiosource

Product Short Name: [Rb1]

Product Name Synonyme: [OSRC; Osteosarcoma; p105-Rb; PP105; pp110; pRb; Prepro retinoblastoma associated protein; RB1; Retinoblastoma 1; Retinoblastoma-associated protein]

Other Names: [retinoblastoma-associated protein; Retinoblastoma-associated protein; retinoblastoma-associated protein; RB transcriptional corepressor 1; p105-Rb; pRb; Rb; pp110]

Product Gene Name: [Rb1]

Product Gene Name Synonyme: N/A

Other Gene Names: [RB1; RB1; RB; pRb; OSRC; pp110; p105-Rb; PPP1R130; Rb]

Clonality: Monoclonal

Isotype: IgG

Clone: [RB1/2313R]

Host: Rabbit

Reactivity: Human, Mouse. Others not known.

Specificity: Recognizes a 105kDa phosphoprotein, identified as retinoblastoma (Rb) gene product. Its epitope is localized between aa 703-772. It shows no cross reaction with p107 or p130. It specifically stains the nuclei of BT-20 cells and primary human foreskin fibroblast (HFF) cells. It does not stain the Rb-negative BT549 cells. It reacts with the hyperphosphorylated as well as the un (under) phosphorylated form of the Rb protein. Retinoblastoma gene product plays a key role in cell cycle control. It has been identified as a tumor suppressor gene whose loss of its function leads to tumor development. It is widely expressed in a variety of human tissues including breast, esophageal, squamous cell and cervical carcinoma.

Purity: N/A

Form: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Concentration: N/A

Storage Stability: Antibody with azide - store at 2 to 8 degree C.
Antibody without azide - store at -20 to -80 degree C.
Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Tested Application: Immunohistochemistry (IHC) Formalin