MBS670344 | Hamster Anti-Mouse CD3e-BIMA

Hamster Anti-Mouse CD3e-BIMA | MBS670344 | MyBiosource

Product Short Name: [CD3e-BIMA]

Product Name Synonyme: [Hamster Anti-Mouse CD3epsilon]

Other Names: N/A

Product Gene Name: N/A

Product Gene Name Synonyme: N/A

Other Gene Names: N/A

Clonality: Monoclonal

Isotype: IgG kappa

Clone: [145-2C11]

Host: Hamster

Reactivity: Mouse

Specificity: Mouse CD3epsilon (Mr 25 kDa)
CD3epsilon, a member of the immunoglobulin superfamily of cell surface receptors, is comprised of five invariable chains ranging in size from 16-28 kDa and is closely associated with the T cell antigen receptor (TCR). It is expressed on all T cells of all mouse strains. CD3 plays a major role in signaling during antigen recognition, leading to T-cell activation. The 145-2C11 monoclonal antibody recognizes an epitope on the 25kD epsilon chain of the CD3/TCR complex. In the presence of Fc receptor-bearing accessory cells, soluble 145-2C11 can activate primed and naïve T cell in vitro. 145-2C11 can also induce redirected lysis of specific target cells by CTL clones and it can block lysis of specific target cells by antigen-specific CTL's. Immobilized 145-2C11 can activate both normal T lymphocytes and cloned T cell lines. Under certain conditions, T cell activation by 145-2C11 may result in apoptotic cell death.

Purity: N/A

Form: Biotin-maleimide (BIMA) Conjugate

Concentration: N/A

Storage Stability: The biotin (BIMA) conjugate is supplied as 0.5 mg in 1.0 mL of PBS/NaN3. Store at 2-8 degree C.

Tested Application: Identification and enumeration of CD3+ cells by Flow Cytometry, Immunoprecipitation, Western Blot, In vitro depletion of CD3+ cells, In vitro activation of T cells, Immunohistochemistry