MBS670336 | Rat Anti-Mouse CD4/L3T4-APC/CY7

Rat Anti-Mouse CD4/L3T4-APC/CY7 | MBS670336 | MyBiosource

Product Short Name: [CD4/L3T4C/CY7]

Product Name Synonyme: [Rat Anti-Mouse CD4/L3T4]

Other Names: N/A

Product Gene Name: N/A

Product Gene Name Synonyme: N/A

Other Gene Names: N/A

Clonality: Monoclonal

Isotype: IgG2b, kappa

Clone: [GK1.5]

Host: Rat

Reactivity: Mouse

Specificity: CD4/L3T4a, Mr 52 kDa
CD4/L3T4 is a type I transmembrane glycoprotein expressed on most thymocytes and the helper/inducer subpopulation of mature T lymphocytes of all mouse strains tested.1,2 CD4 has also been detected at low density on pluripotent hematopoietic stem cells, bone marrow myeloid precursors, and intrathymic lymphoid precursors.3-5 The CD4 antigen functions as a co-receptor, interacting with class II major histocompatability complex (MHC) molecules in the recognition of foreign antigens by T cells.1,2 In vivo and in vitro treatment with the GK1.5 mAb effectively depletes CD4+ cells.7,8 The mAb also blocks helper T cell responses to MHC class II antigens, including cytolysis, proliferation, allogeneic B cell help, and release of lymphokines.1,8-13

Purity: N/A

Form: Allophycocyanin-Cyanine 7 (APC-CY 7) Conjugate

Concentration: N/A

Storage Stability: The Spectral Red (SPRD), R-phycoerythrin -Texas Red (R-PE-TXRD), R-phycoerythrin-Cyanine 7 (RPE- CY 7), R-phycoerythrin-Cyanine 5.5 (R-PE-CY 5.5 Allophycocyanin-Cyanine 5.5 (APC-CY 5.5), and Allophycocyanin- Cyanine 7 (APC-CY 7) conjugates are supplied as 0.1 mg in 1.0 mL of PBS/NaN3 and a stabilizing agent. Store at 2-8 degree C. Do not freeze!

Tested Application: Flow Cytometry, Immunohistochemistry (FS), Immunoprecipitation, In vivo and in vitro depletion of CD4+ cells 6,7, Fractionation of CD4+ cells14