MBS670331 | Rat anti-Human Caspase-2-UNLB

Rat anti-Human Caspase-2-UNLB | MBS670331 | MyBiosource

Product Short Name: [Caspase-2]

Product Name Synonyme: [Rat Anti-Human Caspase 2]

Other Names: [caspase-2; Caspase-2; caspase-2; CASP-2; NEDD-2; protease ICH-1; neural precursor cell expressed developmentally down-regulated protein 2; caspase 2; Neural precursor cell expressed developmentally down-regulated protein 2; NEDD-2; Protease ICH-1]

Product Gene Name: N/A

Product Gene Name Synonyme: N/A

Other Gene Names: [Casp2; Casp2; ICH-1; Nedd2; Caspase-2; Ich1; Nedd-2; Nedd2; CASP-2; NEDD-2]

Clonality: Monoclonal

Isotype: IgM

Clone: [SB123a1]

Host: Rat

Reactivity: Human

Specificity: Reacts with human Caspase 21
The Caspases are a family of cysteine proteases that induce apoptosis in response to a variety of intraand extracellular stimuli. These enzymes are synthesized as inactive precursors which become cleaved at aspartate-specific sites upon induction of apoptosis. Caspase 2 (ICH-1/Nedd2) is an initiator caspase that is prevalent in both the cytosol and nucleus in many cell types3. During embryonic development it is expressed at relatively high levels in the central nervous system, liver, kidney and lungs and is prevalent in numerous tissues in adults4,5. Studies have shown that Caspase 2 becomes activated in response to several lethal stimuli including DNA damage, ER stress and death receptor stimulation and further evidence has suggested a role in reactive oxygen species-induced cell death2,6-9.
The SB123a monoclonal antibody detects bands at ~40 and ~48 kD, corresponding to cleaved and uncleaved forms of Caspase 2, respectively.

Purity: N/A

Form: Purified (UNLB) Antibody

Concentration: N/A

Storage Stability: The purified (UNLB) antibody is supplied as 0.1mg purified immunoglobulin in 0.1 mL of 100 mM borate buffered saline, pH 8.0; store at 2-8 degree C.
Reagents are stable for the period shown on the label if stored as directed.

Tested Application: Western Blot