MBS655374 | MEK1 Inhibitor (PD98059, 2'-amino-3'-methoxyflavone)

MEK1 Inhibitor (PD98059, 2'-amino-3'-methoxyflavone) | MBS655374 | MyBiosource

Product Short Name: [MEK1 Inhibitor]

Product Name Synonyme: N/A

Other Names: [Mitogen-activated protein kinase kinase 1; Dual specificity mitogen-activated protein kinase kinase 1; dual specificity mitogen-activated protein kinase kinase 1; MEK 1; MAPKK 1; MAPK/ERK kinase 1; ERK activator kinase 1; protein kinase, mitogen-activated, kinase 1 (MAP kinase kinase 1); mitogen-activated protein kinase kinase 1; ERK activator kinase 1; MAPK/ERK kinase 1]

Product Gene Name: N/A

Product Gene Name Synonyme: N/A

Other Gene Names: [MAP2K1; MAP2K1; CFC3; MEK1; MKK1; MAPKK1; PRKMK1; MEK1; PRKMK1; MAP kinase kinase 1; MAPKK 1; MKK1; MEK 1]

Clonality: N/A

Isotype: N/A

Clone: N/A

Host: N/A

Reactivity: N/A

Specificity: Inhibits activation of MEK1 and MEK2 with IC50 values of 4uM and 50uM, respectively (1-3). Testing has shown that PD98059 does not inhibit activation of other highly related dual-specificity protein kinases or the activity of over 18 other Ser/Thr protein kinases (3). As shown in the Western Blot, at concentrations up to 100uM PD98059 does not inhibit activation of MKK3 or SEK (MKK4) as determined by measuring phosphorylation at its activation site. We have also found no inhibition of MKK6 or related family members.

Purity: N/A

Form: Supplied as a yellow, lyophilized powder. Reconstitution:

Concentration: N/A

Storage Stability: Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with DMSO. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 6 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer

Tested Application: Western Blot (WB)