MBS6005949 | Myelin Basic Protein, aa82-91 (MBP)

Myelin Basic Protein, aa82-91 (MBP) | MBS6005949 | MyBiosource

Product Short Name: [Myelin Basic Protein, aa82-91]

Product Name Synonyme: [Anti -Myelin Basic Protein, aa82-91 (MBP)]

Other Names: [myelin basic protein; Myelin basic protein; Golli-MBP; myelin basic protein; myelin A1 protein; myelin membrane encephalitogenic protein; myelin basic protein; Myelin A1 protein; Myelin membrane encephalitogenic protein]

Product Gene Name: N/A

Product Gene Name Synonyme: N/A

Other Gene Names: [MBP; MBP; MBP]

Clonality: Monoclonal

Isotype: IgG2a

Clone: [3H2751]

Host: Mouse

Reactivity: Bovine

Specificity: It appears to react with synthetic peptide 82-91 and human and bovine 45-91 but not with whole MBP molecules (Martensen numbering). This epitope is located in the C terminal region of 82-91 and the corresponding epitope is not present (or exposed) in whole MBP.The clone was selected using synthetic human MBP peptide 82-91 for screening (1). Since this work was done a seqence error has been described in the human MBP seqence in this region (3). Although the clone was selected to have a high affinity for 82-91 it appears that this antibody reacts more strongly with the unnatural sequence, rather than the correct human 82-91. In consequence the antibody is not a suitable reagent for sensitive immunoassays of correct human 82-91 as was thought at the time the original paper on this antibody was published (1).The 91-92 phe-phe bond is believed to be cleaved by demyelinating lesions by Cathepsin D to generate peptides ending in the phe 91 which should react with this monoclonal.

Purity: Ascites
Ascites.

Form: Ascites fluid - liquid in with 0.1% sodium azide.

Concentration: N/A

Storage Stability: -20 degree C

Tested Application: ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)