MBS570288 | Mouse anti Melanoma Associated Antigen

Mouse anti Melanoma Associated Antigen | MBS570288 | MyBiosource

Product Short Name: [Melanoma Associated Antigen]

Product Name Synonyme: N/A

Other Names: [melanoma-associated antigen]

Product Gene Name: N/A

Product Gene Name Synonyme: N/A

Other Gene Names: N/A

Clonality: Monoclonal

Isotype: IgG1

Clone: [NKI-C3]

Host: Mouse

Reactivity: Human

Specificity: NKI/C-3 is a MAb which is directed anti a predominantly intracellular protein of Human melanoma cells. The antigen is abundantly present in malignant melanomas, nevocellular nevi, and neuroendocrine tumors, whereas it has not been detectable in most other tissues. The antigen recognized by NKI/C-3 is a glycoprotein which appears as a broad band in SDS-PAGE. The antigen was shown to consist of a single protein backbone to which two or three.V-linked glycans were added cotranslationally. Extensive further heterogeneity was geneRated in the Golgi compartment and was shown to be dependent on the presence of complex type sugars. Although the antigen is associated with melanomas, it was not codistributed with the tyrosinase activity associated with melanogenesis. The antigen did show codistribution with Cathepsin D, which is a marker for lysosomal functions. NKI/C3 originally was described as a marker for melanoma. Recently, it resurfaced as a marker to sepaRate cellular neurothekeoma from other dermal tumors in the differential diagnosis.

Purity: N/A

Form: Each vial contains 1ml of culture supernatant of monoclonal antibody containing 0.09% sodium azide.

Concentration: N/A

Storage Stability: Store at 4 degree C, or in small aliquots at -20 degree C.

Tested Application: ELISA (EIA), Immunofluorescence (IF), Immunohistochemistry (IHC) (frozen), Immunohistochemistry (IHC) (paraffin)