MBS488443 | Anti-Integrin beta-7 [FIB27]

Anti-Integrin beta-7 [FIB27] | MBS488443 | Mybiosource

Product Short Name: [Integrin beta-7]

Product Name Synonyme: [FIB-27; FIB 27; Fib-27; Fib27; Fib 27; fib27; fib-27; fib 27; Integrin b7; integrin b-7; Gut homing receptor beta subunit; FIB27]

Other Names: [integrin beta-7; Integrin beta-7; integrin beta-7; integrin subunit beta 7; Gut homing receptor beta subunit]

Product Gene Name: [ITGB7]

Product Gene Name Synonyme: N/A

Other Gene Names: [ITGB7; ITGB7]

Clonality: Monoclonal

Isotype: Rat IgG2a kappa

Clone: [FIB27]

Host: N/A

Reactivity: Human, Mouse

Specificity: FIB27 binds specifically to both human and mouse integrin beta-7 at epitope region Dl on which is involved in all a4b7-mediated adhesion events. Does not compete with DAKT32 for binding. FIB27 blocks LS722-induced TK1 cell aggregation (mAb LS722 is an activating anti-a4B7 antibody and induces aggregation via an a4B7-dependent pathway). Integrin beta-7 is one subunit is a heterodimer which makes up an intergin molecule. In the mouse beta-7 is selectively found on the majority of mature lymphocytes, whereas a small subpopulation of thymocytes and bone marrow cells express beta-7. Beta-7 is also expressed in variable amounts in CD4 T memory cells. Integrin molecules mediate cell-cell and cell-extracellular matrix adhesion and are involved in lymphocyte homing, leukocyte recruitment to inflammatory sites, myogenesis, hemopoiesis, and melanoma metastasis.

Purity: Protein A Affinity Purified

Form: PBS with 0.02% Proclin 300.

Concentration: 1mg/ml

Storage Stability: Store at 4 degree C for up to 3 months. For longer storage, aliquot and store at -20 degree C.

Tested Application: Flow Cytometry (FC/FACS), Immunoprecipitation (IP), Blocking (BL)