MBS488354 | Anti-CD40 [5D12]

Anti-CD40 [5D12] | MBS488354 | Mybiosource

Product Short Name: [CD40]

Product Name Synonyme: [Tumor necrosis factor receptor superfamily member 5; B-cell surface antigen CD40; Bp50; CD40L receptor; CDw40]

Other Names: [tumor necrosis factor receptor superfamily member 5 isoform 1; Tumor necrosis factor receptor superfamily member 5; tumor necrosis factor receptor superfamily member 5; CD40 molecule; B-cell surface antigen CD40; Bp50; CD40L receptor; CDw40; CD_antigen: CD40]

Product Gene Name: [CD40]

Product Gene Name Synonyme: N/A

Other Gene Names: [CD40; CD40; p50; Bp50; CDW40; TNFRSF5; TNFRSF5]

Clonality: Monoclonal

Isotype: Rabbit IgG, Kappa

Clone: [5D12]

Host: N/A

Reactivity: Cynomolgus, Marmoset Monkey, Human

Specificity: ch5D12 binds specifically to recombinant and native human CD40 ectodomain and has been shown to also bind CD40 in cynomolgus and marmoset monkeys. The antibody requires residues within D1 and D1/B2 for binding (Hager et al, 2003) (D1 domain is crucial for CD40L binding). Binding characteristics are very similar between humanized ch5D12 and mu5D12. CD40 is a glycoprotein of the TNFR superfamily and is expressed on all mature B cells, dendritic cells, activated monocytes, some endothelial cells and some epithelium including the thymus. CD40 binds to CD40L, and this interaction is involved in B-cell activation and proliferation, antigen-presenting cell (APC) activation, initiation of antigen-specific T-cell responses, immunoglobulin production, activation of effector macrophages isotype switching, homotypic adhesion and rescue from apoptosis.

Purity: Protein A Affinity Purified

Form: N/A

Concentration: 1 mg/ml

Storage Stability: Store at 4 degree C for up to 3 months. For longer storage, aliquot and store at -20 degree C.

Tested Application: Block (BL), ELISA (EIA), Flow Cytometry (FC/FACS), Surface Plasmon Resonance (SPR), Immunoprecipitation (IP), Immunohistochemistry (IHC)