MBS439320 | HLA-DRB (MHC II) Mouse Monoclonal Antibody

HLA-DRB (MHC II) Mouse Monoclonal Antibody | MBS439320 | MyBiosource

Product Short Name: [HLA-DRB]

Product Name Synonyme: [DRB1; HLA class II histocompatibility antigen, DR-1 beta chain; HLA-DR-beta 1; HLA-DRB1; human leucocyte antigen DRB1; Leucocyte antigen DR beta 1 chain; lymphocyte antigen DRB1; major histocompatibility complex, class II, DR beta 1; MHC class II HLA-DR beta 1 chain; MHC class II HLA-DR-beta cell surface glycoprotein ]

Other Names: [major histocompatibility complex, class II, DR beta 1; HLA class II histocompatibility antigen, DRB1-15 beta chain; major histocompatibility complex, class II, DR beta 1; major histocompatibility complex, class II, DR beta 1; DW2.2/DR2.2; MHC class II antigen DRB1*15]

Product Gene Name: [HLA-DRB1]

Product Gene Name Synonyme: N/A

Other Gene Names: [HLA-DRB1; HLA-DRB1; SS1; DRB1; DRw10; HLA-DRB; HLA-DR1B; HLA-DRB2]

Clonality: Monoclonal

Isotype: IgG2b, kappa

Clone: [SPM288 ]

Host: Mouse

Reactivity: Human, Monkey.
Does not react with Mouse

Specificity: This MAb reacts with a 28kDa chain of HLA-DRB1 antigen, a member of MHC class II molecules. It does not cross react with HLA-DP and HLA-DQ. The L243 antibody recognizes a different epitope than the LN3 monoclonal antibody, and these antibodies do not cross-block binding to each other's respective epitopes. HLA-DR is a heterodimeric cell surface glycoprotein comprised of a 36kDa alpha (heavy) chain and a 28kDa beta (light) chain. It is expressed on B-cells, activated T-cells, monocytes/macrophages, dendritic cells and other non-professional AP's. In conjunction with the CD3/TCR complex and CD4 molecules, HLA-DR is critical for efficient peptide presentation to CD4+ T cells. It is an excellent histiocytic marker in paraffin sections producing intense staining. True histiocytic neoplasms are similarly positive. HLA-DR antigens also occur on a variety of epithelial cells and their corresponding neoplastic counterparts. Loss of HLA-DR expression is related to tumor microenvironment and predicts adverse outcome in diffuse large B-cell lymphoma.

Purity: N/A

Form: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Concentration: N/A

Storage Stability: Antibody with azide - store at 2 to 8 degree C. Antibody without azide - store at -20 to -80 degree C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Tested Application: Flow Cytometry (FC/FACS), Immunofluorescence (IF), Western Blot (WB), Immunohistochemistry (IHC) Formalin