MBS438739 | GITR / Tnfrsf18 (mouse) Rat Monoclonal Antibody

GITR / Tnfrsf18 (mouse) Rat Monoclonal Antibody | MBS438739 | MyBiosource

Product Short Name: [GITR / Tnfrsf18]

Product Name Synonyme: [Activation-inducible TNF-related ligand; AITRL; GITRL; Glucocorticoid induced TNFR related protein ligand; Glucocorticoid-induced TNF-related ligand; hGITRL; TL6; TNFSF18; Tumor necrosis factor (ligand) superfamily member 18 ]

Other Names: [tumor necrosis factor receptor superfamily member 18 isoform 1; Tumor necrosis factor receptor superfamily member 18; tumor necrosis factor receptor superfamily member 18; tumor necrosis factor receptor superfamily, member 18; Glucocorticoid-induced TNFR-related protein; CD_antigen: CD357]

Product Gene Name: [Tnfrsf18]

Product Gene Name Synonyme: N/A

Other Gene Names: [Tnfrsf18; Tnfrsf18; AITR; Gitr; Gitr]

Clonality: Monoclonal

Isotype: IgG2b, lambda

Clone: [DTA-1 ]

Host: Rat

Reactivity: Mouse

Specificity: GITR (glucocorticoid-induced TNFR-related gene) is a member of the TNF-receptor superfamily, also known as TNFRSF18. It is expressed at low levels on resting T lymphocytes and at high levels on CD25+ CD4+ Tregs. The expression of GITR on T cells can be upregulated upon activation. Interaction of GITR with its ligand (GITRL) has been demonstrated to augment T cell activation, proliferation, cytokine production as well as MAP's and NF-kB activation, and abrogate the inhibitory function of CD25+ CD4+ Tregs. In vivo activation of GITR causes development of autoimmune diseases and restores the suppressed immune response.

Purity: N/A

Form: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Concentration: N/A

Storage Stability: Antibody with azide - store at 2 to 8 degree C. Antibody without azide - store at -20 to -80 degree C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Tested Application: Flow Cytometry (FC/FACS), Immunofluorescence (IF)