MBS438501 | CD33

CD33 | MBS438501 | MyBiosource

Product Short Name: [CD33]

Product Name Synonyme: [gp67; My9; Myeloid cell surface antigen CD33; p67; Sialic acid-binding Ig-like lectin 3 (SIGLEC3)]

Other Names: [myeloid cell surface antigen CD33 isoform 2; Myeloid cell surface antigen CD33; myeloid cell surface antigen CD33; gp67; CD33 antigen (gp67); sialic acid binding Ig-like lectin 3; sialic acid-binding Ig-like lectin 3; CD33 molecule; Sialic acid-binding Ig-like lectin 3; Siglec-3; gp67; CD_antigen: CD33]

Product Gene Name: [CD33]

Product Gene Name Synonyme: N/A

Other Gene Names: [CD33; CD33; p67; SIGLEC3; SIGLEC-3; SIGLEC3; Siglec-3]

Clonality: Monoclonal

Isotype: IgG1, kappa

Clone: [C33/68]

Host: Mouse

Reactivity: Human.

Specificity: Recognizes a 67kDa glycoprotein, which is identified as CD33. It is a transmembrane protein of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. It belongs to the immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing molecules able of recruiting protein tyrosine phosphatases SHP-1 and SHP-2 to signal assemblies; these ITIMs are also used for ubiquitin-mediated removal of the receptor from the cell surface. CD33 is expressed on cells of myelomonocytic lineage, binds sialic acid residues in N- and O-glycans on cell surfaces, and is a therapeutic target for acute myeloid leukemia. CD33 is expressed on myeloid progenitors, monocytes, granulocytes, dendritic cells and mast cells. It is absent on platelets, lymphocytes, erythrocytes and hematopoietic stem cells.

Purity: N/A

Form: N/A

Concentration: N/A

Storage Stability: Store at 2 to 8 degree C. Antibody is stable for 24 months.

Tested Application: ELISA (EIA), Flow Cytometry (FC/FACS), Immunofluorescence (IF), Functional Studies, Immunoprecipitation (IP), Immunohistology (IH)