MBS4381653 | EME1

EME1 | MBS4381653 | Mybiosource

Product Short Name: [EME1]

Product Name Synonyme: [Crossover junction endonuclease EME1; Essential Meiotic Endonuclease 1 Homolog 1/2; hMMS4; MMS4L; SLX2A]

Other Names: [crossover junction endonuclease EME1 isoform 1; Crossover junction endonuclease EME1; crossover junction endonuclease EME1; essential meiotic structure-specific endonuclease 1; MMS4 homolog]

Product Gene Name: [EME1]

Product Gene Name Synonyme: N/A

Other Gene Names: [EME1; EME1; MMS4L; SLX2A; MMS4; hMMS4]

Clonality: Monoclonal

Isotype: IgG1, kappa

Clone: [MTA317H2/1]

Host: Mouse

Reactivity: Human

Specificity: Essential meiotic endonuclease 1 (Eme1), a member of the Eme1/Mms4 family, associates with Mus81 to constitute a heterodimeric endonuclease that has been implicated in mitotic and meiotic recombination in eukaryotes. The Mus81-Eme1 complex cleaves branched DNA structures, especially those arising during stalled DNA replication such as replication forks and 3 DNA flaps. When purified from yeast, this complex cleaves synthetic Holliday junctions into linear duplex DNA. These findings provide compelling evidence that Mus81-Eme1 complexes are essential elements of the eukaryotic nuclear Holliday junction resolvase. Eme1 may also be required in mitosis for the processing of collapsed replication forks. Eme1 is typically localized to the nucleolus and is recruited to regions of DNA damage in S phase cells.

Purity: Purified Ab with BSA and Azide at 200ug/ml or Purified Ab with BSA and Azide at 200ug/ml or Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Form: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Concentration: N/A

Storage Stability: Antibody with azide: store at 2 to 8 degree C.
Antibody without azide: store at -20 to -80 degree C.
Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Tested Application: Immunoprecipitation (IP), Immunofluorescence (IF), Immunohistochemistry (IHC) Paraffin, Western Blot (WB)