MBS4380537 | Crystallin Alpha B

Crystallin Alpha B | MBS4380537 | Mybiosource

Product Short Name: [Crystallin Alpha B]

Product Name Synonyme: [AACRYA; Alpha B crystallin; Alpha-crystallin B chain; CRYA2; CTTP2; Heat shock 20 kD like protein; Heat shock protein beta-5; HspB5; Renal carcinoma antigen NY REN 27; Rosenthal fiber component]

Other Names: [alpha-crystallin B chain isoform 1; Alpha-crystallin B chain; alpha-crystallin B chain; crystallin alpha B; Alpha(B)-crystallin; Heat shock protein beta-5; HspB5; Renal carcinoma antigen NY-REN-27; Rosenthal fiber component]

Product Gene Name: [CRYAB]

Product Gene Name Synonyme: N/A

Other Gene Names: [CRYAB; CRYAB; MFM2; CRYA2; CTPP2; HSPB5; CMD1II; CTRCT16; HEL-S-101; CRYA2; HSPB5; HspB5]

Clonality: Monoclonal

Isotype: IgG2c

Clone: [CPTC-CRYAB-1]

Host: Mouse

Reactivity: Human. Others not tested.

Specificity: Crystallins are the major proteins of the vertebrate eye lens, where they maintain the transparency and refractive index of the lens. Crystallins are divided into alpha, beta and gamma families, and the beta- and gamma-crystallins also compose a superfamily. Crystallins usually contain seven distinct protein regions, including four homologous motifs, a connecting peptide, and N- and C-terminal extensions. alpha-crystallins consist of three gene products, alphaA-, alphaB- and alphaC-crystallin, which are members of the small heat shock protein family (HSP 20). alpha-crystallins act as molecular chaperones by holding denatured proteins in large soluble aggregates. However, unlike other molecular chaperones, alpha-crystallins do not renature these proteins. Expression of alphaA-crystallin is restricted to the lens and defects of this gene cause the development of autosomal dominant congenital cataracts (ADCC). The human alphaB-crystallin gene product is expressed in many tissues, including lens, heart and skeletal muscle. Elevated expression of alphaB-crystallin is associated with many neurological diseases, and a missense mutation in this gene has co-segregated in a family with a Desmin-related myopathy.

Purity: Purified Ab with BSA and Azide at 200ug/ml OR Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Form: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Concentration: N/A

Storage Stability: Antibody with azide - store at 2 to 8 degree C.
Antibody without azide - store at -20 to -80 degree C.
Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Tested Application: Western Blot (WB), Immunohistology (Formalin-Fixed)