MBS4380493 | Spectrin beta III (SPTBN2)

Spectrin beta III (SPTBN2) | MBS4380493 | Mybiosource

Product Short Name: [Spectrin beta III (SPTBN2)]

Product Name Synonyme: [Beta III spectrin; SCA5; Spectrin beta chain brain 2; Spectrin beta non-erythrocytic 2; Spectrin non-erythroid beta chain 2; Spinocerebellar ataxia 5; SPTBN2]

Other Names: [spectrin beta chain, non-erythrocytic 2; Spectrin beta chain, non-erythrocytic 2; spectrin beta chain, non-erythrocytic 2; spectrin beta, non-erythrocytic 2; Beta-III spectrin; Spinocerebellar ataxia 5 protein]

Product Gene Name: [SPTBN2]

Product Gene Name Synonyme: N/A

Other Gene Names: [SPTBN2; SPTBN2; SCA5; SCAR14; GTRAP41; KIAA0302; SCA5]

Clonality: Monoclonal

Isotype: IgG1, kappa

Clone: [SPTBN2/1778]

Host: Mouse

Reactivity: Human. Others not known.

Specificity: Spectrin is an actin binding protein that is a major component of the plasma membrane skeleton. Spectrins function as membrane organizers and stabilizers by forming dimers, tetramers and higher polymers. Vertebrate spectrins have two alpha-subunits (alpha-I/alpha-II), four beta-subunits (beta-I-beta-IV) and a beta-H subunit creating diversity and specialization of function. Spectrin alpha and spectrin beta are present in erythrocytes, whereas spectrin alpha II (also designated fodrin alpha) and spectrin beta I (also designated fodrin beta) are present in other somatic cells. The spectrin tetramers in erythrocytes act as barriers to lateral diffusion, but spectrin dimers seem to lack this function. Spectrin beta III is highly homologous to both spectrin beta I and spectrin beta II. Spectrin beta III is highly expressed in brain, kidney, pancreas and liver, and at lower levels in lung and placenta. Spectrin beta 3 is primarily expressed in nervous tissues with highest expression levels in the cerebellum, where it is found in Purkinje cell soma and dendrites.

Purity: N/A

Form: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Concentration: N/A

Storage Stability: N/A

Tested Application: ELISA (EIA), Immunohistochemistry (IHC) Formalin