MBS4380296 | MAML2 (Mastermind Like Transcriptional Coactivator 2)

MAML2 (Mastermind Like Transcriptional Coactivator 2) | MBS4380296 | Mybiosource

Product Short Name: [MAML2 (Mastermind Like Transcriptional Coactivator 2)]

Product Name Synonyme: [Mam-2; MAML2; Mastermind-like protein 2]

Other Names: [mastermind-like protein 2; Mastermind-like protein 2; mastermind-like protein 2; mastermind like transcriptional coactivator 2]

Product Gene Name: [MAML2]

Product Gene Name Synonyme: N/A

Other Gene Names: [MAML2; MAML2; MAM2; MAM3; MAM-3; MLL-MAML2; KIAA1819; Mam-2]

Clonality: Monoclonal

Isotype: IgG2a

Clone: [MAML2/1302]

Host: Mouse

Reactivity: Human. Others not known.

Specificity: MAML2 (mastermind-like protein 2), also known as MAM2, MAM3 or MLLMAML2, is a nuclear speckle protein that acts as a transcriptional co-activator for Notch receptors. The Notch signaling pathway influences cell fate by regulating the ability of precursor cells to properly respond to developmental signals. MAML2 is a member of the mastermind-like family of proteins that are human homologs of the Drosophila melanogaster mastermind protein. Through its N-terminal region, MAML2 interacts with the ankyrin repeats of the Notch proteins Notch 1, Notch 2, Notch 3 and Notch 4. This interaction leads to formation of a DNA-binding complex with the Notch proteins and RBP-Jkappa; a complex that can then induce HES1 gene expression. While the N-terminal domain of MAML2 is essential for proper Notch binding, the C-terminal domain of MAML2 is essential for transcriptional activation. A chromosomal aberration involving the gene encoding MAML2 is implicated in mucoepidermoid carcinomas, clear cell hidradenomas and benign Warthin tumors.

Purity: N/A

Form: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Concentration: N/A

Storage Stability: Antibody with azide - store at 2 to 8 degree C.
Antibody without azide - store at -20 to -80 degree C.
Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Tested Application: Flow Cytometry (FC/FACS), Immunofluorescence (IF), Western Blot (WB), Immunohistochemistry (IHC) Formalin