MBS224338 | GOAT ANTI HUMAN APH-1A

GOAT ANTI HUMAN APH-1A | MBS224338 | MyBiosource

Product Short Name: [APH-1A]

Product Name Synonyme: N/A

Other Names: [gamma-secretase subunit APH-1A isoform 1; Gamma-secretase subunit APH-1A; gamma-secretase subunit APH-1A; anterior pharynx defective 1 homolog A; aph-1alpha; presenilin-stabilization factor; APH1A gamma secretase subunit; Aph-1alpha; Presenilin-stabilization factor]

Product Gene Name: [APH-1A]

Product Gene Name Synonyme: N/A

Other Gene Names: [APH1A; APH1A; APH-1; APH-1A; CGI-78; 6530402N02Rik; PSF; APH-1a]

Clonality: Polyclonal

Isotype: IgG

Clone: N/A

Host: Goat

Reactivity: Mouse (Expected from Sequence), Rat (Expected from Sequence)

Specificity: This item specifically recognises human APH-1A (gamma-secretase subunit APH-1A), otherwise known as anterior pharynx defective 1 homolog A, an integral transmembrane protein, and member of the APH-1 family, which is predominantly located in the endoplasmic reticulum and cis-Golgi, and is an essential component of the endoprotease gamma-secretase complex.

The gamma-secretase complex, consisting of APH-1 (APH-1A or APH-1B), presenilin-1 or -2 (PSEN1 or PSEN2), nicastrin (NCSTN), and Pen-2 (PEN2), plays a vital role in the evolutionarily conserved Notch signaling pathway, by catalyzing the intramembrane S3 cleavage of ligand-activated Notch receptor proteins (Notch1-4), resulting in the generation and release of an activated NICD fragment, which then translocates to the nucleus and activates the transcription of downstream effector genes.

Purity: N/A

Form: Purified
Purified IgG - liquid

Concentration: IgG concentration 0.5mg/ml

Storage Stability: Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.

Tested Application: ELISA (EIA), Western Blot (WB)