MyBiosource Antibodies
MBS222947 | RABBIT ANTI ORAI3 (N-TERMINAL)
- SKU:
- MBS222947
- Availability:
- Usually Shipped in 5 Working Days
- Size:
- 0.1 mg
Description
RABBIT ANTI ORAI3 (N-TERMINAL) | MBS222947 | MyBiosource
Product Short Name: [ORAI3 ]
Product Name Synonyme: N/A
Other Names: [protein orai-3; Protein orai-3; protein orai-3; transmembrane protein 142C; ORAI calcium release-activated calcium modulator 3; Transmembrane protein 142C]
Product Gene Name: [ORAI3]
Product Gene Name Synonyme: N/A
Other Gene Names: [ORAI3; ORAI3; TMEM142C; TMEM142C]
Clonality: Polyclonal
Isotype: IgG
Clone: N/A
Host: Rabbit
Reactivity: Mouse, Rat
Specificity: This item recognises human ORAI3, also known as Transmembrane protein 142C (TMEM142C), a 31.5 kDa multi-pass membrane protein belonging to the ORAI family.
Antigen stimulation of immune cells triggers Ca2+ entry through Ca2+ release-activated Ca2+ (CRAC) channels. CRAC channels are the main pathway for Ca2+ influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT.
ORAI3 is one of two mammalian homologs of ORAI1, a four- transmembrane spanning protein that is an essential component of CRAC channels. ORAI3, along with ORAI1 and ORAI2, functions as a Ca2+ plasma membrane channel that is gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca2+ sensor. Studies indicate that ORAI3 channels undergo a lesser degree of depotentiation than ORAI1 or ORAI2.
This item is not expected to cross react with either ORAI1 or ORAI2.
Purity: N/A
Form: Purified
Purified IgG - liquid
Concentration: IgG concentration 1.0mg/ml
Storage Stability: Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
Tested Application: Immunohistology Frozen, Western Blot (WB)