MBS222947 | RABBIT ANTI ORAI3 (N-TERMINAL)

RABBIT ANTI ORAI3 (N-TERMINAL) | MBS222947 | MyBiosource

Product Short Name: [ORAI3 ]

Product Name Synonyme: N/A

Other Names: [protein orai-3; Protein orai-3; protein orai-3; transmembrane protein 142C; ORAI calcium release-activated calcium modulator 3; Transmembrane protein 142C]

Product Gene Name: [ORAI3]

Product Gene Name Synonyme: N/A

Other Gene Names: [ORAI3; ORAI3; TMEM142C; TMEM142C]

Clonality: Polyclonal

Isotype: IgG

Clone: N/A

Host: Rabbit

Reactivity: Mouse, Rat

Specificity: This item recognises human ORAI3, also known as Transmembrane protein 142C (TMEM142C), a 31.5 kDa multi-pass membrane protein belonging to the ORAI family.

Antigen stimulation of immune cells triggers Ca2+ entry through Ca2+ release-activated Ca2+ (CRAC) channels. CRAC channels are the main pathway for Ca2+ influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT.

ORAI3 is one of two mammalian homologs of ORAI1, a four- transmembrane spanning protein that is an essential component of CRAC channels. ORAI3, along with ORAI1 and ORAI2, functions as a Ca2+ plasma membrane channel that is gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca2+ sensor. Studies indicate that ORAI3 channels undergo a lesser degree of depotentiation than ORAI1 or ORAI2.

This item is not expected to cross react with either ORAI1 or ORAI2.

Purity: N/A

Form: Purified
Purified IgG - liquid

Concentration: IgG concentration 1.0mg/ml

Storage Stability: Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.

Tested Application: Immunohistology Frozen, Western Blot (WB)