MBS222887 | RABBIT ANTI HUMAN CASPASE-2

RABBIT ANTI HUMAN CASPASE-2 | MBS222887 | MyBiosource

Product Short Name: [CASPASE-2]

Product Name Synonyme: N/A

Other Names: [caspase-2 isoform 2; Caspase-2; caspase-2; neural precursor cell expressed developmentally down-regulated protein 2; protease ICH-1; protein phosphatase 1, regulatory subunit 57; caspase 2, apoptosis-related cysteine peptidase; Neural precursor cell expressed developmentally down-regulated protein 2; NEDD-2; Protease ICH-1Cleaved into the following 3 chains:Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12]

Product Gene Name: N/A

Product Gene Name Synonyme: N/A

Other Gene Names: [CASP2; CASP2; ICH1; NEDD2; CASP-2; NEDD-2; PPP1R57; ICH1; NEDD2; CASP-2; NEDD-2]

Clonality: Polyclonal

Isotype: IgG

Clone: N/A

Host: Rabbit

Reactivity: Mouse

Specificity: This item recognises human caspase-2, a 53 kDa member of the cysteine-aspartic acid protease (caspase) family.

Caspase-2 is required for the permeabilisation of the mitochondria and the resulting amplification of caspase activity, in response to cytotoxic stress. Cytotoxic stress induced proteolytic cleavage of the caspase-2 proenzyme forms an active caspase which cleaves other caspases in a cascade. This leads to the release of cytochrome c and Smac from mitochondria and the translocation of Bax from the cytoplasm to the mitochondria, leading to apoptosis.

In adults, caspase-2 is expressed in the placenta, lung, kidney, pancreas and at lower levels in the heart, brain, liver and skeletal muscle.

Purity: N/A

Form: Purified
Purified IgG - liquid

Concentration: IgG concentration 1.0mg/ml

Storage Stability: Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.

Tested Application: Immunohistology Paraffin*, Western Blot (WB)