MBS222792 | RABBIT ANTI HUMAN CD243

RABBIT ANTI HUMAN CD243 | MBS222792 | MyBiosource

Product Short Name: [CD243]

Product Name Synonyme: N/A

Other Names: [multidrug resistance protein 1; Multidrug resistance protein 1; multidrug resistance protein 1; P-glycoprotein 1; colchicin sensitivity; doxorubicin resistance; ATP-binding cassette, sub-family B (MDR/TAP), member 1; ATP-binding cassette sub-family B member 1; P-glycoprotein 1; CD_antigen: CD243]

Product Gene Name: [CD243]

Product Gene Name Synonyme: N/A

Other Gene Names: [ABCB1; ABCB1; CLCS; MDR1; P-GP; PGY1; ABC20; CD243; GP170; MDR1; PGY1]

Clonality: Polyclonal

Isotype: IgG

Clone: N/A

Host: Rabbit

Reactivity: N/A

Specificity: This item detects CD243, also known as MDR1 (multi-drug resistance protein 1) and P-glycoprotein. CD243 is a 170kDa membrane-associated protein which functions as an ATP-dependent drug efflux pump with broad substrate specificity.

CD243 is highly expressed in the kidney, liver, adrenal gland and intestine, suggesting a primary role in the secretion of metabolites into bile, urine and the lumen of the intestinal tract. CD243 also prevents the accumulation of toxic compounds in critical organs such as the brain, gonads, and bone marrow, and also functions in the placenta to protect the foetus.

CD243 is rapidly up-regulated by chemotherapeutic drugs and is a well established mediator of multidrug resistance.

Purity: N/A

Form: Purified
Purified IgG - liquid

Concentration: IgG concentration 0.5 mg/ml

Storage Stability: Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.

Tested Application: Immunohistology Paraffin*