MBS222771 | RABBIT ANTI HUMAN NOTCH 2

RABBIT ANTI HUMAN NOTCH 2 | MBS222771 | MyBiosource

Product Short Name: [NOTCH 2]

Product Name Synonyme: N/A

Other Names: [neurogenic locus notch homolog protein 2 isoform 2; Neurogenic locus notch homolog protein 2; neurogenic locus notch homolog protein 2; Notch homolog 2; notch 2]

Product Gene Name: [NOTCH 2]

Product Gene Name Synonyme: N/A

Other Gene Names: [NOTCH2; NOTCH2; hN2; AGS2; HJCYS; Notch 2; hN2]

Clonality: Polyclonal

Isotype: IgG

Clone: N/A

Host: Rabbit

Reactivity: Chimpanzee (Expected from Sequence), Dog (Expected from Sequence), Mouse (Expected from Sequence), Rat (Expected from Sequence)

Specificity: This item detects Notch 2, an important signalling protein which is critical for embryonic development. Notch 2 is a type 1 transmembrane protein that is activated by Delta1, Jagged1 and Jagged2. Activation results in cleavage and translocation of the Notch intracellular domain (NICD) to the nucleus, where it functions as a transcriptional regulator.

Notch 2 activation results in differentiation and proliferation in many cells, in particular in myeloid cell differentiation, functioning in the maturation of CD8 thymocytes and the development of Marginal Zone B cells.

Recently Notch 2 mutations have been shown to exist in a minority of patients suffering from Alagille syndrome (AGS), a dominant, multi-system disorder. Notch 2 mutations can also be oncogenic, for example in B-cell chronic lymphocytic leukaemia (B-CLL).

Purity: N/A

Form: Serum
Serum - liquid

Concentration: N/A

Storage Stability: Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.

Tested Application: ELISA (EIA), Western Blot (WB)