MBS221364 | GOAT ANTI HUMAN BID (C-TERMINAL)

GOAT ANTI HUMAN BID (C-TERMINAL) | MBS221364 | MyBiosource

Product Short Name: [BID ]

Product Name Synonyme: N/A

Other Names: [BH3-interacting domain death agonist isoform 2; BH3-interacting domain death agonist; BH3-interacting domain death agonist; BID isoform ES(1b); BID isoform L(2); BID isoform Si6; Human BID coding sequence; apoptic death agonist; desmocollin type 4; p22 BID; BH3 interacting domain death agonist; p22 BID; BID]

Product Gene Name: [BID]

Product Gene Name Synonyme: N/A

Other Gene Names: [BID; BID; FP497; BID]

Clonality: Polyclonal

Isotype: IgG

Clone: N/A

Host: Goat

Reactivity: N/A

Specificity: This item detects an epitope within the C-terminus of BID, a death agonist that heterodimerizes with other members of the Bcl-2 family of cell death regulators; including the agonist BAX or antagonist BCL2.

BID contains a BH3 domain, which is required for its interaction with the Bcl-2 family proteins and for its pro-death activity. BID is susceptible to proteolytic cleavage by caspases, calpains, Granzyme B and cathepsins. Protease-cleaved BID translocates to mitochondria where it results in cytochrome c release, leading to caspase activation and cell death. This constitutes the activation of the mitochondria death pathway (the intrinsic pathway) by the death stimuli.

BID has been shown to promote cell cycle progression into S phase, whilst BID could be also involved in the maintenance of genomic stability by engaging at mitosis checkpoint. Deletion of BID inhibits carcinogenesis in the liver, and promotes tumorigenesis in the myeloid cells.

Purity: N/A

Form: Purified
Purified IgG - liquid

Concentration: IgG concentration 0.5mg/ml

Storage Stability: Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.

Tested Application: ELISA (EIA), Western Blot (WB)