MBS221362 | GOAT ANTI HUMAN CD156b (C-TERMINAL)

GOAT ANTI HUMAN CD156b (C-TERMINAL) | MBS221362 | MyBiosource

Product Short Name: [CD156b ]

Product Name Synonyme: N/A

Other Names: [disintegrin and metalloproteinase domain-containing protein 17 preproprotein; Disintegrin and metalloproteinase domain-containing protein 17; disintegrin and metalloproteinase domain-containing protein 17; ADAM metallopeptidase domain 18; TNF-alpha convertase; TNF-alpha converting enzyme; snake venom-like protease; tumor necrosis factor, alpha, converting enzyme; ADAM metallopeptidase domain 17; Snake venom-like protease; TNF-alpha convertase; TNF-alpha-converting enzyme; CD_antigen: CD156b]

Product Gene Name: [CD156b]

Product Gene Name Synonyme: N/A

Other Gene Names: [ADAM17; ADAM17; CSVP; TACE; NISBD; ADAM18; CD156B; NISBD1; CSVP; TACE; ADAM 17]

Clonality: Polyclonal

Isotype: IgG

Clone: N/A

Host: Goat

Reactivity: Chicken (Expected from Sequence), Hamster (Expected from Sequence), Rat (Expected from Sequence)

Specificity: This item detects an epitope within the C-terminus of isoform 1 of CD156b, a type I transmembrane glycoprotein which belongs to the ADAM (a disintegrin and metalloprotease domain) family. CD156b is 125kD, and functions as a tumour necrosis factor-alpha converting enzyme (TACE). CD156b also causes a number of inflammatory modulators to undergo ectodomain shedding, including TNFR75, IL-1RII, TNFR55, L-selectin, and the amyloid precursor protein among others. CD156b plays a prominent role in the activation of the Notch signalling pathway.
ADAM17 plays a pivotal role in several acquired tumor cell capabilities by mediating the availability of soluble transforming growth factor-alpha, and establishing an autocrine signaling pathway through endogenous EGFR activation. CD156b is therefore a prospective therapeutic target in human cancer.

Purity: N/A

Form: Purified
Purified IgG - liquid

Concentration: N/A

Storage Stability: Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.

Tested Application: ELISA (EIA), Western Blot (WB)