MBS221310 | RABBIT ANTI TSC1

RABBIT ANTI TSC1 | MBS221310 | MyBiosource

Product Short Name: [TSC1]

Product Name Synonyme: N/A

Other Names: [hamartin isoform 1; Hamartin; hamartin; tuberous sclerosis 1 protein; tumor suppressor; tuberous sclerosis 1; Tuberous sclerosis 1 protein]

Product Gene Name: [TSC1]

Product Gene Name Synonyme: N/A

Other Gene Names: [TSC1; TSC1; LAM; TSC; KIAA0243; TSC]

Clonality: Polyclonal

Isotype: IgG

Clone: N/A

Host: Rabbit

Reactivity: Mouse, Rat

Specificity: This item recognises an epitope within the internal region of the 130kDa tumour suppressor protein, Tumour sclerosis complex 1 (TSC1). Mutation within the TSC1 gene is responsible for Tuberous sclerosis (TSC), an autosomal dominant genetic disorder associated with the development of benign tumors (hamartomas), a condition also induced by mutation of the Tumour sclerosis complex 2 (TSC2) gene.
Many proteins have been shown to play a role in the regulation of the serine/threonine kinase known as target of rapamycin (TOR), a central component in a complex signaling pathway which controls cell proliferation and cell cycle progression. Negative regulation of TOR activity occurs following the over-expression of the TSC1 and TSC2 gene products, hamartin and tuberin. These act by suppressing the phosphorylation of eukaryotic translation initiation factor 4E binding protein 1 (4EBP1) and ribosomal protein S6 kinase (S6K), downstream targets of TOR involved in mRNA translation. Furthermore the TOR activator protein Rheb has been identified as a target of TSC1-TSC2 complexes.

This item has been reported as suitable for use in IHC on mouse EL4 cell cytospins at 2ug/ml.

Purity: N/A

Form: Purified
Purified IgG - liquid

Concentration: IgG concentration 1.0mg/ml

Storage Stability: Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.

Tested Application: Immunohistology Frozen, Immunohistology Paraffin, Western Blot (WB)