MBS216090 | RAT ANTI MOUSE CD357

RAT ANTI MOUSE CD357 | MBS216090 | MyBiosource

Product Short Name: [CD357]

Product Name Synonyme: N/A

Other Names: [tumor necrosis factor receptor superfamily member 18 isoform 1; Tumor necrosis factor receptor superfamily member 18; tumor necrosis factor receptor superfamily member 18; glucocorticoid-induced TNFR-related protein; tumor necrosis factor receptor superfamily, member 18; Glucocorticoid-induced TNFR-related protein; CD_antigen: CD357]

Product Gene Name: [CD357]

Product Gene Name Synonyme: N/A

Other Gene Names: [Tnfrsf18; Tnfrsf18; AITR; Gitr; Gitr]

Clonality: Monoclonal

Isotype: IgG2b

Clone: [YGITR765]

Host: Rat

Reactivity: N/A

Specificity: This product recognises mouse CD357, also known as glucocorticoid-induced tumour necrosis factor receptor (mGITR) or Tnrfsf18, a member of the tumour necrosis superfamily. Mouse CD357 is predominantly expressed by CD4+/CD25+ T regulatory cells and on CD4+/CD25- cells upon activation.Studies demonstrate that mouse GITR ligand (mGITRL) can bind to CD357 and neutralise the suppressive effects of CD4+CD25+ regulatory T cells. CD357 signalling can also enhance the proliferation of naïve and primed T cells, suggesting a key role for CD357 in the regulation of T cell-mediated immunity.

Purity: N/A

Form: Purified
Purified IgG - liquid

Concentration: IgG concentration 1.0 mg/ml

Storage Stability: Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.

Tested Application: Flow cytometry (FC/FACS)