MBS214465 | MOUSE ANTI HUMAN CD300a

MOUSE ANTI HUMAN CD300a | MBS214465 | MyBiosource

Product Short Name: [CD300a]

Product Name Synonyme: N/A

Other Names: [CMRF35-like molecule 8 isoform 2; CMRF35-like molecule 8; CMRF35-like molecule 8; CD300 antigen-like family member A; CD300a antigen; CMRF35H leukocyte immunoglobulin-like receptor; NK inhibitory receptor; immunoglobulin superfamily member 12; inhibitory receptor protein 60; leukocyte membrane antigen; CD300a molecule; CD300 antigen-like family member A; CMRF-35-H9; CMRF35-H9; CMRF35-H; IRC1/IRC2; Immunoglobulin superfamily member 12; IgSF12; Inhibitory receptor protein 60; IRp60; NK inhibitory receptor; CD_antigen: CD300a]

Product Gene Name: [CD300a]

Product Gene Name Synonyme: N/A

Other Gene Names: [CD300A; CD300A; IRC1; IRC2; CLM-8; IRp60; IGSF12; CMRF35H; CMRF-35H; CMRF35-H; CMRF35H9; CMRF35-H9; IRC1/IRC2; CMRF-35-H9; CMRF35H; IGSF12; CLM-8; CMRF35-H9; IgSF12; IRp60]

Clonality: Monoclonal

Isotype: IgG1

Clone: [MEM-260]

Host: Mouse

Reactivity: N/A

Specificity: This item specifically recognises human CD300a, otherwise known as IRp60 (inhibitory receptor protein 60), a 60kDa transmembrane glycoprotein expressed by natural killer cells (NK), T and B cell subsets, monocytes, neutrophils, macrophages, granulocytes, dendritic cells (DC) and mast cells.

Studies have shown that the cross-linking of CD300a on NK results in a down-regulation of their cytolytic activity, whilst cross-linking of CD300a on mast cells, inhibits IgE-induced degranulation and SCF-mediated survival. Furthermore, cross-linking of CD300a on the surface of eosinophils has been shown to significantly inhibit their survival, chemotaxis and activation in response to certain inflammatory cytokines, whilst eosinophil-derived MBP (major basic protein) and EDN (neurotoxin), can down-regulate CD300a expression on mast cells in vitro.

Purity: N/A

Form: Purified
Purified IgG - liquid

Concentration: IgG concentration 1.0mg/ml

Storage Stability: Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.

Tested Application: Flow cytometry (FC/FACS), Western Blot (WB)