MyBiosource Antibodies
MBS212750 | MOUSE ANTI FYN
- SKU:
- MBS212750
- Availability:
- Usually Shipped in 5 Working Days
- Size:
- 0.1 mg
Description
MOUSE ANTI FYN | MBS212750 | MyBiosource
Product Short Name: [FYN]
Product Name Synonyme: N/A
Other Names: [tyrosine-protein kinase Fyn isoform a; Tyrosine-protein kinase Fyn; tyrosine-protein kinase Fyn; FYN oncogene related to SRC, FGR, YES; OKT3-induced calcium influx regulator; c-syn protooncogene; proto-oncogene Syn; proto-oncogene c-Fyn; src-like kinase; src/yes-related novel; tyrosine kinase p59fyn(T); FYN proto-oncogene, Src family tyrosine kinase; Proto-oncogene Syn; Proto-oncogene c-Fyn; Src-like kinase; SLK; p59-Fyn]
Product Gene Name: [FYN]
Product Gene Name Synonyme: N/A
Other Gene Names: [FYN; FYN; SLK; SYN; p59-FYN; SLK]
Clonality: Monoclonal
Isotype: IgG2b
Clone: [FYN-01]
Host: Mouse
Reactivity: Mouse
Specificity: This item recognizes p59fyn (fyn), a 59kDa member of the src family of non receptor protein tyrosine kinases, expressed by T cells and Natural Killer (NK) cells and highly expressed in brain.
Fyn plays a vital role in thymocyte development and T cell activation and is essential for TCR-mediated signal transduction through association with the T Cell Receptor (TCR) eta chain/CD3 Complex. This association, results in protein kinase activation and the subsequent protein tyrosine phosphorylation of multiple immunoreceptor tyrosine-based activation motifs (ITAMs), which triggers the phosphorylation of further substrates downstream in the T cell signaling cascade.
Recent studies into Alzheimer's Disease have implicated fyn in neurodegeneration, through the tyrosine phosphorylation of the microtubule-associated protein tau, a prominent component of neurofibrillary tangles.
Purity: N/A
Form: Purified
Purified IgG - liquid
Concentration: IgG concentration 1.0 mg/ml
Storage Stability: Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody.
Shelf Life: 18 months from date of despatch.
Tested Application: Immunohistology Frozen, Immunoprecipitation (IP), Western Blot (WB)