MBS212750 | MOUSE ANTI FYN

MOUSE ANTI FYN | MBS212750 | MyBiosource

Product Short Name: [FYN]

Product Name Synonyme: N/A

Other Names: [tyrosine-protein kinase Fyn isoform a; Tyrosine-protein kinase Fyn; tyrosine-protein kinase Fyn; FYN oncogene related to SRC, FGR, YES; OKT3-induced calcium influx regulator; c-syn protooncogene; proto-oncogene Syn; proto-oncogene c-Fyn; src-like kinase; src/yes-related novel; tyrosine kinase p59fyn(T); FYN proto-oncogene, Src family tyrosine kinase; Proto-oncogene Syn; Proto-oncogene c-Fyn; Src-like kinase; SLK; p59-Fyn]

Product Gene Name: [FYN]

Product Gene Name Synonyme: N/A

Other Gene Names: [FYN; FYN; SLK; SYN; p59-FYN; SLK]

Clonality: Monoclonal

Isotype: IgG2b

Clone: [FYN-01]

Host: Mouse

Reactivity: Mouse

Specificity: This item recognizes p59fyn (fyn), a 59kDa member of the src family of non receptor protein tyrosine kinases, expressed by T cells and Natural Killer (NK) cells and highly expressed in brain.

Fyn plays a vital role in thymocyte development and T cell activation and is essential for TCR-mediated signal transduction through association with the T Cell Receptor (TCR) eta chain/CD3 Complex. This association, results in protein kinase activation and the subsequent protein tyrosine phosphorylation of multiple immunoreceptor tyrosine-based activation motifs (ITAMs), which triggers the phosphorylation of further substrates downstream in the T cell signaling cascade.

Recent studies into Alzheimer's Disease have implicated fyn in neurodegeneration, through the tyrosine phosphorylation of the microtubule-associated protein tau, a prominent component of neurofibrillary tangles.

Purity: N/A

Form: Purified
Purified IgG - liquid

Concentration: IgG concentration 1.0 mg/ml

Storage Stability: Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody.
Shelf Life: 18 months from date of despatch.

Tested Application: Immunohistology Frozen, Immunoprecipitation (IP), Western Blot (WB)