MBS157892 | Anti Extracellular Death Factor mouse monoclonal antibody

Anti Extracellular Death Factor mouse monoclonal antibody | MBS157892 | Mybiosource

Product Short Name: [Extracellular Death Factor]

Product Name Synonyme: [Description: mazEF is a toxin-antitoxin stress-induced module which is abundant on the chromosome of most bacteria including pathogens and most extensively studied in Escherichia coli. E Coli mazEF mediated cell death is a population phenomenon requiring the quorum-sensing (QS) -Extracellular Death Factor' (EDF) ; the E Coli peptide NNWNN. Penta-peptide NNWNN (EcEDF) enhances the endoribonucleolytic activity of E Coli toxin MazF. The newly discovered extracellular death factor (EDF) is a pentapeptide with the sequence NNWNN in Escherichia coli. It was reported that it participated in the cell death process mediated by toxin-antitoxin system mazEF. Reactive oxygen species (ROS) are recently considered as common factors for bactericidal antibiotics-mediated cell death. Previous study indicated that EDF could scavenge hydroxyl radicals and might act as a signal molecule with dual effects; ���death��� and ���survival���. But the structure-activity relationship of EDF and the effects of EDF on the activity of antibiotics remain unclear. In the present study; our results indicated that tryptophan could be the key residue to the hydroxyl radicals-scavenging activity of EDF; and EDF could protect Escherichia coli from killing by bactericidal antibiotics; but not by DNA-damaging or bacteriostatic antibiotics. Our results could provide novel evidence to understand the role of EDF in drug-resistance.]

Other Names: [glucose-6-phosphate 1-dehydrogenase; Glucose-6-phosphate 1-dehydrogenase; glucose-6-phosphate 1-dehydrogenase]

Product Gene Name: N/A

Product Gene Name Synonyme: N/A

Other Gene Names: [zwf; zwf; ECK1853; JW1841; EDF]

Clonality: Monoclonal

Isotype: IgG2b

Clone: [93-D-4]

Host: Mouse

Reactivity: N/A

Purity: Protein G purified from mice ascites

Form: Liquid. PBS, pH7.4, containing 0.05% proclin300, 50% glycerol

Concentration: 1mg/ml

Storage Stability: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 degree C for frequent use. Store at -20 to -80 degree C for ~12 months from the date of receipt

Tested Application: Elisa (EIA), Immunohistochemistry (IHC)