Stearyl Linolenyl Phosphatidate

Stearyl linolenyl phosphatidate (SLAP) is a phospholipid that is a component of cell membranes. It is made up of a stearyl alcohol group, a linolenic acid group, and a phosphate group. SLAP is important for cell membrane structure and function. It also plays a role in a variety of cellular processes, including cell signaling, metabolism, and inflammation.

Here are some of the important functions of SLAP:

  • Cell membrane structure and function: SLAP is a major component of cell membranes. It helps to give cell membranes their flexibility and fluidity. SLAP also helps to protect cells from the environment.
  • Cell signaling: SLAP can act as a signaling molecule to trigger various cellular responses. For example, SLAP can activate protein kinases, which are enzymes that regulate cell growth, differentiation, and apoptosis.
  • Metabolism: SLAP is involved in the metabolism of fatty acids. It helps to transport fatty acids into cells and to convert them into energy.
  • Inflammation: SLAP can play a role in both acute and chronic inflammation. In acute inflammation, SLAP can help to recruit immune cells to the site of injury. In chronic inflammation, SLAP can contribute to the development of diseases such as atherosclerosis and cancer.

SLAP deficiency is rare, but it can occur in people with certain genetic disorders. SLAP deficiency can lead to a variety of health problems, including neurological problems, liver disease, and lung disease.

SLAP is an important phospholipid that plays a role in a variety of cellular processes. SLAP deficiency can lead to a number of serious health problems.

MBS6106211 | Stearyl Palmitate
MBS393392 | Stearyl Laurate
MBS393400 | Stearyl Myristate
MBS393409 | Stearyl Palmitate
MBS393419 | Stearyl Stearate
MBS393427 | Stearyl Arachidate
MBS393435 | Stearyl Behenate
MBS393444 | Stearyl Oleate
MBS393452 | Stearyl Linoleate
MBS393459 | Stearyl Myristoleate
MBS393461 | Stearyl Linolenate
MBS393462 | Stearyl Palmitoleate
MBS393464 | Stearyl Arachidonate
MBS3610379 | Stearyl glycyrrhetinate


Accession Number : KLM0000349 This work is released into the public domain; please see our release statement.
Doug Markham has contributed a molecular mechanics computation of the structure! See below for the details.

 stearyl-linolenyl-phosphatidate-3d.gif

Config Rule :

 

% 'stearyl-linolenyl-phosphatidate'


config('stearyl-linolenyl-phosphatidate',[
        substituent('L-glycerol-3-phosphate-1,2-di-yl'),
        substituent(linolenyl),
        substituent(stearyl),
        linkage(from('L-glycerol-3-phosphate-1,2-di-yl',attach_to([oxy,car(1)])),
                to(stearyl,car(1)),
                nil,single),
        linkage(from('L-glycerol-3-phosphate-1,2-di-yl',attach_to([oxy,car(2)])),
                to(linolenyl,car(1)),
                nil,single)]).

config('L-glycerol-3-phosphate-1,2-di-yl',[
        chain([
                oxymethyl,
                car(2,(oxy~)&&hyd;),
                methylphosphate])]).

config('L-glycerol-3-phosphate-1,2-di-yl',[
        chain([
                oxymethyl,
                car(2,(oxy~)&&hyd;),
                methylphosphate])]).

config(linolenyl,[
        chain([
                ketyl(1),
                num(methandiyl,7),
                car(9,hyd)~~,
                car(10,hyd),
                methandiyl,
                car(12,hyd)~~,
                car(13,hyd),
                methandiyl,
                car(15,hyd)~~,
                car(16,hyd),
                methandiyl,
                methyl]),
        cis(car(8),car(11),bond(car(9),car(10))),
        cis(car(11),car(14),bond(car(12),car(13))),
        cis(car(14),car(17),bond(car(15),car(16)))]).

config(stearyl,[
        chain([
                ketyl(1),
                num(methandiyl,16),
                methyl])]).

Smiles String :

 

[C@2H2]([O][C]([C@2H2][C@2H2][C@2H2][C@2H2][C@2H2][C@2H2][C@2H2][C@2H2][C@2H2][_
C@2H2][C@2H2][C@2H2][C@2H2][C@2H2][C@2H2][C@2H2][CH3])=[O])[C@2H]([O][C]([C@2H2_
][C@2H2][C@2H2][C@2H2][C@2H2][C@2H2][C@2H2]\[CH]=[CH]/[C@2H2]\[CH]=[CH]/[C@2H2]_
\[CH]=[CH]/[C@2H2][CH3])=[O])[C@2H2][O][P@2](=[O])([O-])[O-]

'stearyl-linolenyl-phosphatidate'

Fischer Diagram :

 

Terminal :

% 'stearyl-linolenyl-phosphatidate'

c(1,12,(0,nonchiral))-[o(2,left)~,h(1,right)~,h(2,up)~,c(2,down)~],
c(2,12,(0,chiral))-[o(3,left)~,h(3,right)~,c(1,up)~,c(3,down)~],
c(3,12,(0,nonchiral))-[h(4,left)~,h(5,right)~,c(2,up)~,o(1,down)~],
c(4,12,(0,nonchiral))-[o(7,nil)~~,c(5,right)~,o(2,nil)~],
c(5,12,(0,nonchiral))-[c(4,left)~,c(6,right)~,h(7,up)~,h(6,down)~],
c(6,12,(0,nonchiral))-[c(5,left)~,c(7,right)~,h(9,up)~,h(8,down)~],
c(7,12,(0,nonchiral))-[c(6,left)~,c(8,right)~,h(11,up)~,h(10,down)~],
c(8,12,(0,nonchiral))-[c(7,left)~,c(9,right)~,h(13,up)~,h(12,down)~],
c(9,12,(0,nonchiral))-[c(8,left)~,c(10,right)~,h(15,up)~,h(14,down)~],
c(10,12,(0,nonchiral))-[c(9,left)~,c(11,right)~,h(17,up)~,h(16,down)~],
c(11,12,(0,nonchiral))-[c(10,left)~,c(12,right)~,h(19,up)~,h(18,down)~],
c(12,12,(0,nonchiral))-[c(11,left)~,c(13,right)~,h(21,up)~,h(20,down)~],
c(13,12,(0,nonchiral))-[c(12,left)~,c(14,right)~,h(23,up)~,h(22,down)~],
c(14,12,(0,nonchiral))-[c(13,left)~,c(15,right)~,h(25,up)~,h(24,down)~],
c(15,12,(0,nonchiral))-[c(14,left)~,c(16,right)~,h(27,up)~,h(26,down)~],
c(16,12,(0,nonchiral))-[c(15,left)~,c(17,right)~,h(29,up)~,h(28,down)~],
c(17,12,(0,nonchiral))-[c(16,left)~,c(18,right)~,h(31,up)~,h(30,down)~],
c(18,12,(0,nonchiral))-[c(17,left)~,c(19,right)~,h(33,up)~,h(32,down)~],
c(19,12,(0,nonchiral))-[c(18,left)~,c(20,right)~,h(35,up)~,h(34,down)~],
c(20,12,(0,nonchiral))-[c(19,left)~,c(21,right)~,h(37,up)~,h(36,down)~],
c(21,12,(0,nonchiral))-[c(20,left)~,h(38,right)~,h(40,up)~,h(39,down)~],
c(22,12,(0,nonchiral))-[o(8,nil)~~,c(23,right)~,o(3,nil)~],
c(23,12,(0,nonchiral))-[c(22,left)~,c(24,right)~,h(42,up)~,h(41,down)~],
c(24,12,(0,nonchiral))-[c(23,left)~,c(25,right)~,h(44,up)~,h(43,down)~],
c(25,12,(0,nonchiral))-[c(24,left)~,c(26,right)~,h(46,up)~,h(45,down)~],
c(26,12,(0,nonchiral))-[c(25,left)~,c(27,right)~,h(48,up)~,h(47,down)~],
c(27,12,(0,nonchiral))-[c(26,left)~,c(28,right)~,h(50,up)~,h(49,down)~],
c(28,12,(0,nonchiral))-[c(27,left)~,c(29,right)~,h(52,up)~,h(51,down)~],
c(29,12,(0,nonchiral))-[c(28,left)~,h(53,right)~,h(54,up)~,c(30,(down,isomeric(down)))~],
c(30,12,(0,nonchiral))-[h(55,(nil,isomeric(down)))~,c(29,(up,isomeric(up)))~,c(31,cis)~~],
c(31,12,(0,nonchiral))-[c(32,(right,isomeric(up)))~,h(56,(nil,isomeric(down)))~,c(30,cis)~~],
c(32,12,(0,nonchiral))-[c(31,(left,isomeric(down)))~,c(33,(right,isomeric(down)))~,h(58,up)~,h(57,down)~],
c(33,12,(0,nonchiral))-[c(32,(left,isomeric(up)))~,h(59,(nil,isomeric(down)))~,c(34,cis)~~],
c(34,12,(0,nonchiral))-[c(35,(right,isomeric(up)))~,h(60,(nil,isomeric(down)))~,c(33,cis)~~],
c(35,12,(0,nonchiral))-[c(34,(left,isomeric(down)))~,c(36,(right,isomeric(down)))~,h(62,up)~,h(61,down)~],
c(36,12,(0,nonchiral))-[c(35,(left,isomeric(up)))~,h(63,(nil,isomeric(down)))~,c(37,cis)~~],
c(37,12,(0,nonchiral))-[c(38,(right,isomeric(up)))~,h(64,(nil,isomeric(down)))~,c(36,cis)~~],
c(38,12,(0,nonchiral))-[c(37,(left,isomeric(down)))~,c(39,right)~,h(66,up)~,h(65,down)~],
c(39,12,(0,nonchiral))-[c(38,left)~,h(67,right)~,h(69,up)~,h(68,down)~],
h(1,1,(0,nonchiral))-[c(1,left)~],
h(2,1,(0,nonchiral))-[c(1,down)~],
h(3,1,(0,nonchiral))-[c(2,left)~],
h(4,1,(0,nonchiral))-[c(3,right)~],
h(5,1,(0,nonchiral))-[c(3,left)~],
h(6,1,(0,nonchiral))-[c(5,up)~],
h(7,1,(0,nonchiral))-[c(5,down)~],
h(8,1,(0,nonchiral))-[c(6,up)~],
h(9,1,(0,nonchiral))-[c(6,down)~],
h(10,1,(0,nonchiral))-[c(7,up)~],
h(11,1,(0,nonchiral))-[c(7,down)~],
h(12,1,(0,nonchiral))-[c(8,up)~],
h(13,1,(0,nonchiral))-[c(8,down)~],
h(14,1,(0,nonchiral))-[c(9,up)~],
h(15,1,(0,nonchiral))-[c(9,down)~],
h(16,1,(0,nonchiral))-[c(10,up)~],
h(17,1,(0,nonchiral))-[c(10,down)~],
h(18,1,(0,nonchiral))-[c(11,up)~],
h(19,1,(0,nonchiral))-[c(11,down)~],
h(20,1,(0,nonchiral))-[c(12,up)~],
h(21,1,(0,nonchiral))-[c(12,down)~],
h(22,1,(0,nonchiral))-[c(13,up)~],
h(23,1,(0,nonchiral))-[c(13,down)~],
h(24,1,(0,nonchiral))-[c(14,up)~],
h(25,1,(0,nonchiral))-[c(14,down)~],
h(26,1,(0,nonchiral))-[c(15,up)~],
h(27,1,(0,nonchiral))-[c(15,down)~],
h(28,1,(0,nonchiral))-[c(16,up)~],
h(29,1,(0,nonchiral))-[c(16,down)~],
h(30,1,(0,nonchiral))-[c(17,up)~],
h(31,1,(0,nonchiral))-[c(17,down)~],
h(32,1,(0,nonchiral))-[c(18,up)~],
h(33,1,(0,nonchiral))-[c(18,down)~],
h(34,1,(0,nonchiral))-[c(19,up)~],
h(35,1,(0,nonchiral))-[c(19,down)~],
h(36,1,(0,nonchiral))-[c(20,up)~],
h(37,1,(0,nonchiral))-[c(20,down)~],
h(38,1,(0,nonchiral))-[c(21,left)~],
h(39,1,(0,nonchiral))-[c(21,up)~],
h(40,1,(0,nonchiral))-[c(21,down)~],
h(41,1,(0,nonchiral))-[c(23,up)~],
h(42,1,(0,nonchiral))-[c(23,down)~],
h(43,1,(0,nonchiral))-[c(24,up)~],
h(44,1,(0,nonchiral))-[c(24,down)~],
h(45,1,(0,nonchiral))-[c(25,up)~],
h(46,1,(0,nonchiral))-[c(25,down)~],
h(47,1,(0,nonchiral))-[c(26,up)~],
h(48,1,(0,nonchiral))-[c(26,down)~],
h(49,1,(0,nonchiral))-[c(27,up)~],
h(50,1,(0,nonchiral))-[c(27,down)~],
h(51,1,(0,nonchiral))-[c(28,up)~],
h(52,1,(0,nonchiral))-[c(28,down)~],
h(53,1,(0,nonchiral))-[c(29,left)~],
h(54,1,(0,nonchiral))-[c(29,down)~],
h(55,1,(0,nonchiral))-[c(30,(nil,isomeric(up)))~],
h(56,1,(0,nonchiral))-[c(31,(nil,isomeric(up)))~],
h(57,1,(0,nonchiral))-[c(32,up)~],
h(58,1,(0,nonchiral))-[c(32,down)~],
h(59,1,(0,nonchiral))-[c(33,(nil,isomeric(up)))~],
h(60,1,(0,nonchiral))-[c(34,(nil,isomeric(up)))~],
h(61,1,(0,nonchiral))-[c(35,up)~],
h(62,1,(0,nonchiral))-[c(35,down)~],
h(63,1,(0,nonchiral))-[c(36,(nil,isomeric(up)))~],
h(64,1,(0,nonchiral))-[c(37,(nil,isomeric(up)))~],
h(65,1,(0,nonchiral))-[c(38,up)~],
h(66,1,(0,nonchiral))-[c(38,down)~],
h(67,1,(0,nonchiral))-[c(39,left)~],
h(68,1,(0,nonchiral))-[c(39,up)~],
h(69,1,(0,nonchiral))-[c(39,down)~],
o(1,16,(0,nonchiral))-[p(1,right)~,c(3,up)~],
o(2,16,(0,nonchiral))-[c(4,nil)~,c(1,right)~],
o(3,16,(0,nonchiral))-[c(22,nil)~,c(2,right)~],
o(4,16,(-6.666666666666666E-01,nonchiral))-[p(1,left)?],
o(5,16,(-6.666666666666666E-01,nonchiral))-[p(1,up)?],
o(6,16,(-6.666666666666666E-01,nonchiral))-[p(1,down)?],
o(7,16,(0,nonchiral))-[c(4,nil)~~],
o(8,16,(0,nonchiral))-[c(22,nil)~~],
p(1,31,(0,nonchiral))-[o(1,left)~,o(4,right)?,o(6,up)?,o(5,down)?]

The Terminals for all the Config Rules are in Prolog Definite Clause Grammar (DCG) form.They can be checked in the Manual here.

The compound's PDB file can be seen here.

Doug Markham of the Institute for Cancer Research, Fox Chase Cancer Center,Philadelphia, PA, has contributed the following structure for stearyl-linolenyl-phosphatidate. He computed this structure in sdf format using MacroModel, a molecular mechanics program. We have used Babel to convert the .sdf format to PDB format. You'll find it interesting to compare these structures to those computed using CONCORD.

Many thanks Doug!