Choline kinase
Choline kinase, also known as CK, ChoK, and choline phosphokinase, is an enzyme critical for the initial step in the choline pathway, facilitating the biosynthesis of phosphatidylcholine (PC). By transferring a phosphate group from adenosine triphosphate (ATP) to choline, it generates phosphocholine, with ATP and choline as substrates and adenosine diphosphate (ADP) and O-phosphocholine as products. Magnesium ions (+2) act as a necessary cofactor for its function. Choline kinase, together with its related forms CKα-1, CKα-2, and CKβ, encoded by the genes CHKA and CHKB, plays essential roles in various metabolic processes. ChoK, a cytosolic enzyme, phosphorylates choline to produce phosphorylcholine (PCho) and is crucial for synthesizing vital membrane phospholipids. It has also been implicated in malignant transformation in a variety of human tumors, making it an intriguing target for the development of selective antitumor agents and potential therapeutic interventions in various diseases.
Accession Number : KLM0000086This work is released into the public domain; please see our release statement.
| MBS1249498 | Recombinant Rat Choline/ethanolamine kinase (Chkb) |
| MBS1259052 | Recombinant Mouse Choline/ethanolamine kinase (Chkb) |
| MBS573757 | Rabbit anti Saccharomyces cerevisiae Choline kinase |
| MBS621516 | CHKB (choline kinase beta, CHETK, CHKL, choline kinase-like, choline/ethanolamine kinase) |
| MBS767897 | Choline kinase alpha Rabbit Polyclonal |
| MBS767898 | Choline kinase alpha-Specific Rabbit Polyclonal |
| MBS849847 | Choline Kinase B, Human Recombinant |
| MBS2123417 | Recombinant Choline Kinase Beta (CHKb) |
| MBS6373884 | CHKB (Choline/Ethanolamine Kinase, Choline/Ethanolamine Kinase beta, CKEKB, Choline Kinase beta, CKB, CK, Choline Kinase-like Protein, Ethanolamine Kinase, Ethanolamine Kinase beta, CHETK, CHKL) (AP) |
| MBS6373885 | CHKB (Choline/Ethanolamine Kinase, Choline/Ethanolamine Kinase beta, CKEKB, Choline Kinase beta, CKB, CK, Choline Kinase-like Protein, Ethanolamine Kinase, Ethanolamine Kinase beta, CHETK, CHKL) APC |
| MBS6373886 | CHKB (Choline/Ethanolamine Kinase, Choline/Ethanolamine Kinase beta, CKEKB, Choline Kinase beta, CKB, CK, Choline Kinase-like Protein, Ethanolamine Kinase, Ethanolamine Kinase beta, CHETK, CHKL) (Biotin) |
| MBS6373887 | CHKB (Choline/Ethanolamine Kinase, Choline/Ethanolamine Kinase beta, CKEKB, Choline Kinase beta, CKB, CK, Choline Kinase-like Protein, Ethanolamine Kinase, Ethanolamine Kinase beta, CHETK, CHKL) (FITC) |
| MBS6373888 | CHKB (Choline/Ethanolamine Kinase, Choline/Ethanolamine Kinase beta, CKEKB, Choline Kinase beta, CKB, CK, Choline Kinase-like Protein, Ethanolamine Kinase, Ethanolamine Kinase beta, CHETK, CHKL) (HRP) |
| MBS6373889 | CHKB (Choline/Ethanolamine Kinase, Choline/Ethanolamine Kinase beta, CKEKB, Choline Kinase beta, CKB, CK, Choline Kinase-like Protein, Ethanolamine Kinase, Ethanolamine Kinase beta, CHETK, CHKL) (MaxLight 405) |
| MBS6373890 | CHKB (Choline/Ethanolamine Kinase, Choline/Ethanolamine Kinase beta, CKEKB, Choline Kinase beta, CKB, CK, Choline Kinase-like Protein, Ethanolamine Kinase, Ethanolamine Kinase beta, CHETK, CHKL) (MaxLight 490) |
| MBS6373891 | CHKB (Choline/Ethanolamine Kinase, Choline/Ethanolamine Kinase beta, CKEKB, Choline Kinase beta, CKB, CK, Choline Kinase-like Protein, Ethanolamine Kinase, Ethanolamine Kinase beta, CHETK, CHKL) (MaxLight 550) |
| MBS6373892 | CHKB (Choline/Ethanolamine Kinase, Choline/Ethanolamine Kinase beta, CKEKB, Choline Kinase beta, CKB, CK, Choline Kinase-like Protein, Ethanolamine Kinase, Ethanolamine Kinase beta, CHETK, CHKL) (MaxLight 650) |
| MBS6373893 | CHKB (Choline/Ethanolamine Kinase, Choline/Ethanolamine Kinase beta, CKEKB, Choline Kinase beta, CKB, CK, Choline Kinase-like Protein, Ethanolamine Kinase, Ethanolamine Kinase beta, CHETK, CHKL) (MaxLight 750) |
| MBS6373894 | CHKB (Choline/Ethanolamine Kinase, Choline/Ethanolamine Kinase beta, CKEKB, Choline Kinase beta, CKB, CK, Choline Kinase-like Protein, Ethanolamine Kinase, Ethanolamine Kinase beta, CHETK, CHKL) (PE) |
| MBS9603295 | Choline kinase alpha Antibody |
Config Rule :
% choline
config(choline,[
chain([
hydroxymethyl,
methandiyl,
nit(1,methyl&&methyl;&&methyl;)])]).
Smiles String :
[C@2H2]([C@2H2][N@2+]([CH3])([CH3])[CH3])[OH]
choline
Fischer Diagram :
Terminal :
% choline
c(1,12,(0,nonchiral))-[c(2,left)~,h(1,right)~,o(1,up)~,h(2,down)~],
c(2,12,(0,nonchiral))-[h(4,left)~,c(1,right)~,h(5,up)~,n(1,down)~],
c(3,12,(0,nonchiral))-[h(6,left)~,n(1,right)~,h(7,up)~,h(8,down)~],
c(4,12,(0,nonchiral))-[n(1,left)~,h(9,right)~,h(11,up)~,h(10,down)~],
c(5,12,(0,nonchiral))-[h(12,left)~,h(14,right)~,n(1,up)~,h(13,down)~],
h(1,1,(0,nonchiral))-[c(1,left)~],
h(2,1,(0,nonchiral))-[c(1,up)~],
h(3,1,(0,nonchiral))-[o(1,nil)~],
h(4,1,(0,nonchiral))-[c(2,right)~],
h(5,1,(0,nonchiral))-[c(2,down)~],
h(6,1,(0,nonchiral))-[c(3,right)~],
h(7,1,(0,nonchiral))-[c(3,down)~],
h(8,1,(0,nonchiral))-[c(3,up)~],
h(9,1,(0,nonchiral))-[c(4,left)~],
h(10,1,(0,nonchiral))-[c(4,up)~],
h(11,1,(0,nonchiral))-[c(4,down)~],
h(12,1,(0,nonchiral))-[c(5,right)~],
h(13,1,(0,nonchiral))-[c(5,up)~],
h(14,1,(0,nonchiral))-[c(5,left)~],
n(1,14,(1,nonchiral))-[c(3,left)~,c(4,right)~,c(2,up)~,c(5,down)~],
o(1,16,(0,nonchiral))-[h(3,nil)~,c(1,down)~]
The Terminals for all the Config Rules are in Prolog Definite Clause Grammar (DCG) form.They can be checked in the Manual here.
The compound's PDB file can be seen here.
