L-aspartate

L'acide aspartique, often denoted by the symbol Asp or D, represents a fundamental α-amino acid crucial in the realm of protein synthesis. Within this amino acid, the L enantiomer serves as one of the essential 22 proteinogenic amino acids, with its genetic coding mediated through the specific GAU and GAC codons on messenger RNA. Its molecular structure is defined by the presence of a carboxyl group –COOH at the terminus of its lateral chain, contributing to its remarkably low isoelectric point of 2.77, positioning it as the most acidic residue within the realm of proteins. Its anion and conjugate base are known as aspartate, while its van der Waals radius measures 291 picometers, emphasizing its significant molecular scale interactions and steric influences within biological systems.

Functionally, as a dicarboxylic acid, aspartic acid embodies a polar molecular entity, playing a pivotal role in various physiological processes. In the context of mammalian physiology, it assumes a non-essential role, indicating that the mammalian system is proficient in endogenous synthesis. Furthermore, its critical involvement in the urea cycle metabolism underscores its intricate contributions to the intricate tapestry of biochemical pathways, highlighting its significance in fundamental biological processes and metabolic homeostasis.

MBS1008867 | Recombinant L-asparagine permease 2 (ansP2)
MBS1034950 | Recombinant L-asparagine permease 1 (ansP1)
MBS1078555 | Recombinant L-asparagine permease 2 (ansP2)
MBS1242017 | Recombinant Escherichia coli L-asparagine permease (ansP)
MBS358026 | Polyclonal anti-conjugated NO-L-asparagine antibodies
MBS358294 | NO-L-Asparagine (BSA) conjugate
MBS405164 | L-Asparagine; H2O
MBS545538 | L-Asparagine, anhydrous
MBS545960 | L-ASPARAGINE monohydrate
MBS610808 | Nitroso-L-Asparagine (NO-L-Asparagine), Conjugated
MBS6040936 | L-Asparagine Monohydrate
MBS6046858 | L-Asparagine Anhydrous
MBS6091000 | Tosyl-L-asparagine
MBS7087673 | Recombinant L-asparagine permease 1 (ansP1), partial
MBS7102501 | Recombinant Streptomyces coelicolor L-asparagine permease (ansP), partial
MBS3609013 | L-Asparagine
MBS3609745 | Nalpha-Acetyl-L-asparagine
MBS3611592 | L(+)-Asparagine monohydrate
MBS4158199 | Anti-Conjugated NO-L-Asparagine Antibody
MBS5750179 | L-Asparagine


Accession Number : KLM0000077 This work is released into the public domain; please see our release statement.

Synonyms :

L-ASPARTATE
Asp
D
Config Rule :

config('L-aspartate',[
substituent(aminoacid_L_backbone),
substituent(methandiylcarboxyl),
linkage(from(aminoacid_L_backbone,car(1)),
to(methandiylcarboxyl,car(1)),
down,single)]).

%%%% Substituent Config Rules for compound 'L-aspartate' %%%%

config(aminoacid_L_backbone,[
left(amino),
right(hyd),
top(carboxyl),
center(car(1))]).

config(methandiylcarboxyl,[
top(car(1,hyd&&hyd;)),
bottom(carboxyl)]).

Smiles String :

[C@2H]([NH3+])([C](=[O])[O-])[C@2H2][C](=[O])[O-]

'L-aspartate'

Fischer Diagram :


Terminal :

% 'L-aspartate'

c(1,12,(0,chiral))-[n(1,left)~,h(1,right)~,c(2,up)~,c(3,down)~],
c(2,12,(0,nonchiral))-[o(1,nil)?,o(2,nil)?,c(1,down)~],
c(3,12,(0,nonchiral))-[c(4,left)~,h(5,right)~,c(1,up)~,h(6,down)~],
c(4,12,(0,nonchiral))-[o(3,nil)?,c(3,right)~,o(4,nil)?],
h(1,1,(0,nonchiral))-[c(1,left)~],
h(2,1,(0,nonchiral))-[n(1,right)~],
h(3,1,(0,nonchiral))-[n(1,down)~],
h(4,1,(0,nonchiral))-[n(1,up)~],
h(5,1,(0,nonchiral))-[c(3,left)~],
h(6,1,(0,nonchiral))-[c(3,up)~],
n(1,14,(1,nonchiral))-[h(2,left)~,c(1,right)~,h(3,up)~,h(4,down)~],
o(1,16,(-5.0E-01,nonchiral))-[c(2,nil)?],
o(2,16,(-5.0E-01,nonchiral))-[c(2,nil)?],
o(3,16,(-5.0E-01,nonchiral))-[c(4,nil)?],
o(4,16,(-5.0E-01,nonchiral))-[c(4,nil)?]

The Terminals for all the Config Rules are in Prolog Definite Clause Grammar (DCG) form.They can be checked in the Manual here.

The compound's PDB file can be seen here.