MBS673518 | Hamster Anti-Mouse CD152/CTLA-4-UNLB

Hamster Anti-Mouse CD152/CTLA-4-UNLB | MBS673518 | MyBiosource

Product Short Name: [CD152/CTLA-4]

Product Name Synonyme: [Hamster Anti-Mouse CD152/CTLA-4 - Purified, Unlabeled Antibody; Hamster Anti-Mouse CD152/CTLA-4]

Other Names: N/A

Product Gene Name: N/A

Product Gene Name Synonyme: N/A

Other Gene Names: N/A

Clonality: Monoclonal

Isotype: Syrian Hamster IgG kappa

Clone: [9H10]

Host: Syrian Hamster

Reactivity: Mouse

Specificity: Mouse CD152/CTLA-4 costimulatory receptor, Mr 69 kDa
CD152, also known as CTLA-4, is homologous to the costimulatory molecule CD28.^1,2 Like CD28, the CD152 molecule binds the family of B7 counter-receptors (CD80/B7-1 and CD86/B7-2) on antigenpresenting cells.^3 CTLA-4 is not expressed on resting T lymphocytes but is induced 2-3 days following T-cell stimulation via the T cell receptor (TCR) complex.^1,3,4 Whereas CD28 provides a positive costimulatory signal, CD152/CTLA-4 is a negative regulator of T-cell activation, possibly by inhibiting tyrosine kinase signalling through the TCR through its association with tyrosine phosphatases such as SHP-2.^1,5,6

Purity: N/A

Form: Purified (UNLB) Antibody

Concentration: N/A

Storage Stability: The purified (UNLB) antibody is supplied as 0.5 mg of purified immunoglobulin in 1.0 mL of 100 mM borate buffered saline, pH 8.0. No preservatives or amine-containing buffer salts added. Store at 2- 8 degree C.
The low endotoxin, azide-free (LE/AF) antibody is supplied as 0.5 mg purified immunoglobulin in 1.0 mL of PBS. Aliquot and store at or below -20 degree C.
With the exception of the low endotoxin, azide-free product, the vials should be stored at 2-8 degree C. Aliquot and freeze the low endotoxin, azide-free product at -20 degree C immediately upon receipt. Each reagent is stable for the period shown on the bottle label if stored as directed.

Tested Application: Flow Cytometry; Immunoprecipitation