MBS670008 | Mouse Anti-Bax-UNLB

Mouse Anti-Bax-UNLB | MBS670008 | MyBiosource

Product Short Name: [Bax]

Product Name Synonyme: [Mouse Anti-Bax - Purified, Unlabeled Antibody; Mouse Anti-Bax]

Other Names: [bax; Apoptosis regulator BAX; apoptosis regulator BAX; Bcl2-associated X protein]

Product Gene Name: N/A

Product Gene Name Synonyme: N/A

Other Gene Names: [Bax; Bax; Bax]

Clonality: Monoclonal

Isotype: Mouse IgG1

Clone: [6A7]

Host: Mouse

Reactivity: N/A

Specificity: Human, mouse and rat Bax (Mr 20-22 kDa)
Apoptosis, or programmed cell death, is a well-documented phenomenon in many cellular systems.2 It plays a key role in tissue and organ development as well as in adult tissues during cell turnover. Apoptosis can be induced by a variety of internal and external stimuli including growth factor deprivation, cytokine treatment, antigen-receptor engagement, cell-cell interactions, irradiation and glucocorticoid treatment.3 Bax is a member of the Bcl-2 family of apoptosis-associated proteins and, although it is similar in structure to Bcl-2, Bax exerts a pro-apoptotic rather than an anti-apoptotic effect on cells. Bax targets mitochondrial membranes, inducing mitochondrial damage and subsequent cell death in a caspase-independent manner, presumably via their ion channel-forming activity. These channels may then function to promote a mitochondrial permeability transition or to puncture the outer mitochondrial membrane. In addition to forming homodimer, Bax can heterodimerize with Bcl-2 and Bcl-XL proteins. This heterodimerization between pro- and anti-apoptotic family members may serve a titration function and act as a sensor for the programmed cell death program.4-13 The monoclonal antibody 2D2 is specific for human Bax.1

Purity: N/A

Form: Purified (UNLB) Antibody

Concentration: N/A

Storage Stability: The purified (UNLB) antibody is supplied as 0.1 mg of purified immunoglobulin in 1.0 mL of 100 mM borate buffered saline, pH 8.2. No preservatives or amine-containing buffer salts added. Store at 2-8 degree C.
The products should be stored at 2-8 degree C. Each product is stable for the period shown on the label if stored as directed.

Tested Application: ELISA; Immunofluorescence; Immunoprecipitation; Western Blot