MBS439694 | IDH1 (Isocitrate Dehydrogenase) Mouse Monoclonal Antibody

IDH1 (Isocitrate Dehydrogenase) Mouse Monoclonal Antibody | MBS439694 | MyBiosource

Product Short Name: [IDH1 (Isocitrate Dehydrogenase) ]

Product Name Synonyme: [Cytosolic NADP-isocitrate dehydrogenase; Epididymis luminal protein 216; Epididymis secretory protein Li 26; HEL-216; HEL-S-26; ICDH; IDCD; IDH1; IDP; IDPC; Isocitrate dehydrogenase [NADP] cytoplasmic; Isocitrate dehydrogenase 1 (NADP+) soluble; NADP dependent isocitrate dehydrogenase peroxisomal; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase; PICD ]

Other Names: [isocitrate dehydrogenase; Isocitrate dehydrogenase [NADP] cytoplasmic; isocitrate dehydrogenase [NADP] cytoplasmic; isocitrate dehydrogenase (NADP(+)) 1, cytosolic; Cytosolic NADP-isocitrate dehydrogenase; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase]

Product Gene Name: [IDH1]

Product Gene Name Synonyme: N/A

Other Gene Names: [IDH1; IDH1; IDH; IDP; IDCD; IDPC; PICD; HEL-216; HEL-S-26; PICD; IDH]

Clonality: Monoclonal

Isotype: IgG1, kappa

Clone: [IDH1/1152 ]

Host: Mouse

Reactivity: Human.
Others not known

Specificity: It recognizes a 45kDa protein, which is identified as isocitrate dehydrogenase (IDH1). It belongs to the isocitrate and isopropylmalate dehydrogenases family. IDH1 catalyzes the third step of the citric acid cycle, which involves the oxidative decarboxylation of isocitrate, forming alpha-ketoglutarate and CO2 in a two-step reaction. The first step involves the oxidation of isocitrate to the intermediate oxalosuccinate, while the second step involves the production of alpha-ketoglutarate. During this process, either NADH or NADPH is produced along with CO2. Recently, an inactivating mutation of IDH1 has been implicated in glioblastoma. IDH1 appears to function as a tumor suppressor that, when mutationally inactivated, contributes to tumorigenesis in part through induction of the HIF-1 pathway.

Purity: N/A

Form: 7.0ml of Ready-to-Use for IHC staining of formalin-fixed tissues.

Concentration: N/A

Storage Stability: Store at 2 to 8 degree C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Tested Application: Flow Cytometry (FC/FACS), Immunofluorescence (IF), Western Blot (WB), Immunohistochemistry (IHC) Formalin