MBS439178 | Cytochrome C (Mitochondrial Marker) Mouse Monoclonal Antibody

Cytochrome C (Mitochondrial Marker) Mouse Monoclonal Antibody | MBS439178 | MyBiosource

Product Short Name: [Cytochrome C]

Product Name Synonyme: [CYC; CYCS; HCS; THC4 ]

Other Names: [cytochrome c; Cytochrome c; cytochrome c; cytochrome c, somatic]

Product Gene Name: [CYCS]

Product Gene Name Synonyme: N/A

Other Gene Names: [CYCS; CYCS; CYC; HCS; THC4; CYC]

Clonality: Monoclonal

Isotype: IgG2b, kappa

Clone: [CYCS/1010 ]

Host: Mouse

Reactivity: Human, Rat.
Others not known

Specificity: Cytochrome C is a well-characterized mobile electron transport protein that is essential to energy conversion in all aerobic organisms. In mammalian cells, this highly conserved protein is normally localized to the mitochondrial inter-membrane space. More recent studies have identified cytosolic cytochrome c as a factor necessary for activation of apoptosis. During apoptosis, cytochrome c is trans-located from the mitochondrial membrane to the cytosol, where it is required for activation of caspase-3 (CPP32). Overexpression of Bcl-2 has been shown to prevent the translocation of cytochrome c, thereby blocking the apoptotic process. Overexpression of Bax has been shown to induce the release of cytochrome c and to induce cell death. The release of cytochrome c from the mitochondria is thought to trigger an apoptotic cascade, whereby Apaf-1 binds to Apaf-3 (caspase-9) in a cytochrome c-dependent manner, leading to caspase-9 cleavage of caspase-3. This MAb recognizes total cytochrome C which includes both apocytochrome (i.e. cytochrome in the cytosol without heme attached) and holocytochrome (i.e cytochrome in the mitochondria with heme attached).

Purity: N/A

Form: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 1mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Concentration: N/A

Storage Stability: Antibody with azide - store at 2 to 8 degree C. Antibody without azide - store at -20 to -80 degree C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Tested Application: Flow Cytometry (FC/FACS), Immunofluorescence (IF), Western Blot (WB), Immunohistochemistry (IHC) Formalin