MBS438370 | Cyclin B1

Cyclin B1 | MBS438370 | MyBiosource

Product Short Name: [Cyclin B1]

Product Name Synonyme: [CCNB; CCNB1; CCNB1_HUMAN; G2 Mitotic Specific Cyclin B1]

Other Names: [G2/mitotic-specific cyclin-B1; G2/mitotic-specific cyclin-B1; G2/mitotic-specific cyclin-B1; G2/mitotic-specific cyclin B1; cyclin B1]

Product Gene Name: [CCNB1]

Product Gene Name Synonyme: N/A

Other Gene Names: [CCNB1; CCNB1; CCNB; CCNB]

Clonality: Monoclonal

Isotype: IgG1, kappa

Clone: [V92.1]

Host: Mouse

Reactivity: Human, Mouse, Hamster.

Specificity: It recognizes a protein of 55-62kDa, identified as cyclin B1. In mammals, cyclin B associates with inactive p34cdc2, which facilitates phosphorylation of p34cdc2 at aa 14Thr and 15Tyr. This maintains the inactive state until the end of G2-phase. The inactive cyclin B-p34cdc2 complex continues to accumulate in the cytoplasm until the completion of DNA synthesis, when Cdc25, a specific protein phosphatase, dephosphorylates aa 14Thr and 15Tyr of p34cdc2 rendering the complex active at the G2/M boundary. This mitotic kinase complex remains active until the metaphase/anaphase transition when cyclin B is degraded. This degradation process is ubiquitin-dependent and is necessary for the cell to exit mitosis. So, cyclin B-p34cdc2 plays a critical role in G2 to M transition.

Purity: N/A

Form: N/A

Concentration: N/A

Storage Stability: Store at 2 to 8 degree C. Antibody is stable for 24 months.

Tested Application: ELISA (EIA), Flow Cytometry (FC/FACS), Immunofluorescence (IF), Immunoprecipitation (IP), Western Blot (WB), Immunohistology (IH)