MBS438363 | FOXP3 (Forkhead Box Protein P3) / Scurfin Mouse Monoclonal Antibody

FOXP3 (Forkhead Box Protein P3) / Scurfin Mouse Monoclonal Antibody | MBS438363 | MyBiosource

Product Short Name: [FOXP3 (Forkhead Box Protein P3) / Scurfin]

Product Name Synonyme: [JM2, AIID, DIETER, IPEX, MGC141961, MGC141963, PIDX, XPID, FOXP3delta7, forkhead box protein P3, immune dysregulation, polyendocrinopathy, enteropathy, X-linked, immunodeficiency, polyendocrinopathy, enteropathy, X-linked, scurfin ]

Other Names: [forkhead box protein P3 isoform b; Forkhead box protein P3; forkhead box protein P3; forkhead box P3; Scurfin]

Product Gene Name: [FOXP3]

Product Gene Name Synonyme: N/A

Other Gene Names: [FOXP3; FOXP3; JM2; AIID; IPEX; PIDX; XPID; DIETER; IPEX]

Clonality: Monoclonal

Isotype: IgG1, kappa

Clone: [FXP3/197 ]

Host: Mouse

Reactivity: Human, Monkey, Mouse

Specificity: Recognizes a protein of 47-55kDa, which is identified as FOXP3. Its precise epitope is not known, but it has been mapped to the N-terminal portion of the protein. The FOX family of transcription factors is a large group of proteins that share a common DNA binding domain termed a winged-helix or forkhead domain. During early development, FOXP1 and FOXP2 are expressed abundantly in the lung, with lower levels of expression in neural, intestinal and cardiovascular tissues, where they act as transcription repressors. FOXP1 is widely expressed in adult tissues, while neoplastic cells often exhibit a dramatic change in expression level or localization of FOXP1. Mutations in FOXP3 gene cause IPEX, a fatal, X-linked inherited disorder characterized by immune dysregulation. The FOXP3 protein is essential for normal immune homeostasis. Specifically, FOXP3 represses transcription through a DNA binding forkhead domain, thereby regulating T cell activation.

Purity: N/A

Form: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Concentration: N/A

Storage Stability: Antibody with azide - store at 2 to 8 degree C. Antibody without azide - store at -20 to -80 degree C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Tested Application: Flow Cytometry (FC/FACS), Immunofluorescence (IF), Immunohistochemistry (IHC) Formalin