MBS438295 | CD46 (Membrane Cofactor Protein) Mouse Monoclonal Antibody

CD46 (Membrane Cofactor Protein) Mouse Monoclonal Antibody | MBS438295 | MyBiosource

Product Short Name: [CD46]

Product Name Synonyme: [AHUS2; CD46 antigen complement regulatory protein; Complement membrane cofactor protein; MCP; Measles virus receptor; Membrane cofactor protein; MIC10; TLX; Trophoblast leucocyte common antigen ]

Other Names: [membrane cofactor protein isoform 1; Membrane cofactor protein; membrane cofactor protein; CD46 molecule; TLX; Trophoblast leukocyte common antigen; CD_antigen: CD46]

Product Gene Name: [CD46]

Product Gene Name Synonyme: N/A

Other Gene Names: [CD46; CD46; MCP; TLX; AHUS2; MIC10; TRA2.10; MCP; MIC10]

Clonality: Monoclonal

Isotype: IgG1, kappa

Clone: [122.2]

Host: Mouse

Reactivity: Human

Specificity: CD46 acts as a cofactor for complement factor I, a serine protease, which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. It may be involved in the fusion of the spermatozoa with the oocyte during fertilization. CD46 acts as a co-stimulatory factor for T-cells, which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.

Purity: N/A

Form: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Concentration: N/A

Storage Stability: Antibody with azide - store at 2 to 8 degree C. Antibody without azide - store at -20 to -80 degree C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Tested Application: Functional Studies, Flow Cytometry (FC/FACS), Immunofluorescence (IF)