MBS438155 | SUMO-2/3 Mouse Monoclonal Antibody

SUMO-2/3 Mouse Monoclonal Antibody | MBS438155 | MyBiosource

Product Short Name: [SUMO-2/3 ]

Product Name Synonyme: [Recombinant human SUMO2 protein ]

Other Names: [small ubiquitin-related modifier 2 isoform b; Small ubiquitin-related modifier 2; small ubiquitin-related modifier 2; small ubiquitin-like modifier 2; HSMT3]

Product Gene Name: [SUMO2]

Product Gene Name Synonyme: [SUMO3]

Other Gene Names: [SUMO2; SUMO2; HSMT3; SMT3B; SUMO3; Smt3A; SMT3H2; Smt3B]

Clonality: Monoclonal

Isotype: IgG1, kappa

Clone: [SM23/496 ]

Host: Mouse

Reactivity: Human.
Predicted to show a broad species reactivity

Specificity: This MAb reacts with both SUMO-2 and SUMO-3. The small ubiquitin-related modifier (SUMO) proteins, which include SUMO-1, 2 and 3, belong to the ubiquitin-like protein family. Like ubiquitin, the SUMO proteins are synthesized as precursor proteins that undergo processing before conjugation to target proteins. Also, both utilize the E1, E2 and E3 cascade enzymes for conjugation. However, SUMO and ubiquitin differ with respect to targeting. Ubiquitination predominantly targets proteins for degradation, whereas sumoylation targets proteins to a variety of cellular processing, including nuclear transport, transcriptional regulation, apoptosis and protein stability. The unconjugated SUMO-1, 2 and 3 proteins localize to the nuclear membrane, nuclear bodies and cytoplasm, respectively. SUMO-1 utilizes Ubc9 for conjugation to several target proteins, which include MDM2, p53, PML and RanGap1. SUMO-2 and 3 contribute to a greater percentage of protein modification than does SUMO-1 and unlike SUMO-1, they can form polymeric chains. In addition, SUMO-3 regulates beta-Amyloid generation and may be critical in the onset or progression of Alzheimer's disease.

Purity: N/A

Form: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Concentration: N/A

Storage Stability: Antibody with azide - store at 2 to 8 degree C. Antibody without azide - store at -20 to -80 degree C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Tested Application: Flow Cytometry (FC/FACS), Immunofluorescence (IF), Western Blot (WB), Immunohistochemistry (IHC) Formalin