MBS4381535 | CD137, Mouse

CD137, Mouse | MBS4381535 | Mybiosource

Product Short Name: [CD137]

Product Name Synonyme: [4-1BB ligand receptor; 4-1BB; Mouse; homolog; CD137; HLDA VI; induced by lymphocyte activation (ILA); Interleukin activated receptor homolog of Mouse Ly63; Ly63; Mouse; Receptor protein 4 1BB; T cell antigen ILA; T-cell antigen 4-1BB homolog; T-cell antigen ILA; TNF receptor superfamily member 9; Tumor necrosis factor receptor superfamily member 9 (TNFRSF9)]

Other Names: [tumor necrosis factor receptor superfamily member 9 isoform 1; Tumor necrosis factor receptor superfamily member 9; tumor necrosis factor receptor superfamily member 9; tumor necrosis factor receptor superfamily, member 9; 4-1BB ligand receptor; T-cell antigen 4-1BB; CD_antigen: CD137]

Product Gene Name: [CD137]

Product Gene Name Synonyme: [Tnfrsf9]

Other Gene Names: [Tnfrsf9; Tnfrsf9; ILA; Ly63; 4-1BB; Cd137; CDw137; AA408498; AI325004; A930040I11Rik; Cd137; Ila; Ly63]

Clonality: Monoclonal

Isotype: IgG2a, kappa

Clone: [LOB12]

Host: Rat

Reactivity: Mouse
Does not react with Human.

Specificity: CD137 (4-1BB), a member of the tumor necrosis factor receptor superfamily, is a type I transmembrane glycoprotein expressed on the cell surface of activated splenic T cells and thymocytes. The functions of CD137 in T lymphocytes include regulating activation, proliferation and apoptosis. CD137 and CD28 are costimulatory molecules of T cell activation. Costimulatory molecules are important in initiating anti-tumor immune responses. CD137 plays an important role in regulating T-cell-dependent immune responses. Expression of CD137 correlates negatively with lymphocyte proliferation and positively with the degree of activation-induced cell death caused by mitogen overstimulation. In monocytes, CD137 induces activation, promotes adherence and prolongs survival. The LOB12.3 antibody is an agonistic antibody that has been shown to stimulate 4-1BB signaling and delay tumor growthin vivowhen administered in combination with immune checkpoint inhibitors.

Purity: Purified Ab with BSA and Azide at 200ug/ml OR Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Form: 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Concentration: N/A

Storage Stability: Antibody with azide: store at 2 to 8 degree C.
Antibody without azide: store at -20 to -80 degree C.
Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Tested Application: Functional Studies, Flow Cytometry (FC/FACS), Immunofluorescence (IF)