MBS4381356 | Alpha Actinin 4/ACTN4

Alpha Actinin 4/ACTN4 | MBS4381356 | Mybiosource

Product Short Name: [Alpha Actinin 4/ACTN4]

Product Name Synonyme: [F-actin cross-linking protein; Focal segmental glomerulosclerosis 1 (FSG1); Non-muscle alpha-actinin-4]

Other Names: [Alpha-actinin-4; Alpha-actinin-4; alpha-actinin-4; actinin alpha 4; F-actin cross-linking protein; Non-muscle alpha-actinin 4]

Product Gene Name: [ACTN4]

Product Gene Name Synonyme: N/A

Other Gene Names: [ACTN4; ACTN4; FSGS; FSGS1; ACTININ-4]

Clonality: Monoclonal

Isotype: IgG

Clone: [93]

Host: Mouse

Reactivity: Human

Specificity: The spectrin gene family encodes a diverse group of cytoskeletal proteins that include spectrins, dystrophins and -actinins. There are four tissue-specific -actinins, namely -actinin-1, -actinin-2, -actinin-3 and -actinin-4, which are localized to muscle and non-muscle cells, including skeletal, cardiac and smooth muscle cells, as well as within the cytoskeleton. Each -actinin protein contains one Actin-binding domain, two calponin-homology domains, two EF-hand domains and four spectrin repeats, through which they function as bundling proteins that can cross-link F-Actin, thus anchoring Actin to a variety of intracellular structures. Defects in the gene encoding -actinin-4 are the cause of focal segmental glomerulosclerosis 1 (FSGS1), a common renal lesion characterized by decreasing kidney function and, ultimately, renal failure.

Purity: Purified Ab with BSA and Azide at 200ug/ml OR Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Form: 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Concentration: N/A

Storage Stability: Antibody with azide: store at 2 to 8 degree C.
Antibody without azide: store at -20 to -80 degree C.
Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Tested Application: Immunohistochemistry (IHC) Paraffin