MBS4381276 | STAT5B

STAT5B | MBS4381276 | Mybiosource

Product Short Name: [STAT5B]

Product Name Synonyme: [Signal transducer and activator of transcription 5B; STAT5; Stat5b; Transcription factor STAT5B]

Other Names: [signal transducer and activator of transcription 5B; Signal transducer and activator of transcription 5B; signal transducer and activator of transcription 5B; signal transducer and activator of transcription 5B]

Product Gene Name: [STAT5B]

Product Gene Name Synonyme: N/A

Other Gene Names: [STAT5B; STAT5B; STAT5]

Clonality: Monoclonal

Isotype: IgG

Clone: [STAT5B/2657]

Host: Mouse

Reactivity: Human

Specificity: Signal transducer and activator of transcription 5A (Stat5a) and Stat5b, which share 96% homology, undergo receptor tyrosine kinase or G protein-coupled receptor-dependent phosphorylation in response to cytokines or growth factors, and then form homo- or heterodimers that translocate to the nucleus, where they initiate transcription. Activation of Stat5a via IL-2, IL-3, IL-7/ GM-CSF, erythropoietin, thrombopoietin and growth hormones influences proliferation, differentiation and apoptosis in lymphohematopoietic cells. Phosphorylation of Stat5a at Ser127/Ser128 and Ser779 are contigent on ErbB-4-mediated activation of Stat5a. Activation of Stat5b via IL-2, IL-4, CSF-1 and growth hormones influences TCR signaling, apoptosis, adult mammary gland development and sexual dimorphism of liver gene expression. Stat5b is the major liver-expressed Stat5 form that has been shown to fuse with the retinoic acid receptor a gene in acute promyelocytic leukemias (APLL). Stat5a/b null mice have severely impaired lymphoid development and differentiation.

Purity: Purified Ab with BSA and Azide at 200ug/ml OR Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Form: 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Concentration: N/A

Storage Stability: Antibody with azide: store at 2 to 8 degree C.
Antibody without azide: store at -20 to -80 degree C.
Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Tested Application: ELISA (EIA)