MBS4381193 | Calcineurin B/PPP3R1

Calcineurin B/PPP3R1 | MBS4381193 | Mybiosource

Product Short Name: [Calcineurin B/PPP3R1]

Product Name Synonyme: [Calcineurin B; type I (19kDa); Calcineurin subunit B type 1; CALNB1; CNB1; PPP3R1 protein phosphatase 3 (formerly 2B); regulatory subunit B; alpha isoform; Protein phosphatase 3 regulatory subunit B alpha; Protein phosphatase 3 regulatory subunit B alpha isoform 1]

Other Names: [Calcineurin subunit B type 1; Calcineurin subunit B type 1; calcineurin subunit B type 1; protein phosphatase 3 regulatory subunit B, alpha; Protein phosphatase 2B regulatory subunit 1; Protein phosphatase 3 regulatory subunit B alpha isoform 1]

Product Gene Name: [PPP3R1]

Product Gene Name Synonyme: N/A

Other Gene Names: [PPP3R1; PPP3R1; CNB; CNB1; CALNB1; CNA2; CNB]

Clonality: Monoclonal

Isotype: IgG1, kappa

Clone: [CALNB/2342]

Host: Mouse

Reactivity: Human

Specificity: Calcineurin is an enzyme that dephosphorylates serine and threonine residues in proteins. It is a heterodimer of a 59kDa catalytic A subunit and a 19kDa regulatory B subunit that is activated by the binding of calcium ions and calmodulin. Calcineurin is expressed in many tissues, but its levels are highest in the brain, where it may play a role in learning and memory. It has many substrates, including NFAT, a transcription factor that is activated by dephosphorylation. Complexes of the immuno-suppressants cyclosporine and FK506 with immunophilin proteins such as cyclophilin and FKBP12 are potent and specific inhibitors of Calcineurin activity. Alterations in Calcineurin activity are suspected to play a role in cardiac hypertrophy and graft versus host disease in organ transplantation.

Purity: Purified Ab with BSA and Azide at 200ug/ml OR Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Form: 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Concentration: N/A

Storage Stability: Antibody with azide: store at 2 to 8 degree C.
Antibody without azide: store at -20 to -80 degree C.
Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Tested Application: Immunohistochemistry (IHC) Paraffin